Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 15/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27590 | 0.82 | HPGDS (0.59) | HPGDSCYP3A4USP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL28861 | 0.74 | HPGDS (0.71) | HPGDSCYP3A4USP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL27841 | 0.71 | HPGDS (1.00) | HPGDSCYP3A4USP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL27589 | 0.68 | HPGDS (1.00) | HPGDS | |
| Morpholine SCHEMBL28316 | 0.67 | HPGDS (0.59) | HPGDSCYP3A4USP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL27787 | 0.67 | HPGDS (1.00) | HPGDS | |
| SCHEMBL29363 | 0.66 | HPGDS (1.00) | HPGDS | |
| SCHEMBL28315 | 0.65 | HPGDS (1.00) | HPGDSCYP3A4 | |
| SCHEMBL28755 | 0.65 | HPGDS (1.00) | HPGDS | |
| SCHEMBL23017395 | 0.64 | HPGDS (0.73) | HPGDSCYP3A4USP2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407466-A1 | PIPERAZINE COMPOUND CAPABLE OF INHIBITING PROSTAGLANDIN D SYNTHASE | Taiho Pharmaceutical Co., Ltd. (JP) | 2012-01-18 | — | — | EP | disclosed |