2-Pyrrolidone

2-Pyrrolidone

SCHEMBL28862005

F.F.F.O=C1CCCN1.S

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 1/20 0.88
CRBN Q96SW2 5/20 0.74
FKBP5 Q13451 1/20 0.74
KDM4E B2RXH2 2/20 0.43
GAA P10253 2/20 0.43
POLB P06746 1/20 0.43
LMNA P02545 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HSD17B10 Q99714 1/20 0.33
TP53 P04637 1/20 0.33
TSHR P16473 1/20 0.33
CA1 P00915 1/20 0.32
CA9 Q16790 1/20 0.32
KMT2A Q03164 1/20 0.31
HSP90AA1 P07900 1/20 0.31
GRIA1 P42261 1/20 0.31
GRIA2 P42262 1/20 0.31
GRIA3 P42263 1/20 0.31
GRIA4 P48058 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Pyrrolidone SCHEMBL27545029 0.97
2-Pyrrolidone SCHEMBL4300422 0.97
2-Pyrrolidone SCHEMBL28332073 0.94
2-Pyrrolidone SCHEMBL2167448 0.94 OR51E2 (1.00) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL4299593 0.94
2-Pyrrolidone SCHEMBL2389 0.94
2-Pyrrolidone SCHEMBL27827832 0.94
2-Pyrrolidone SCHEMBL9304498 0.94 OR51E2 (1.00) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL2518866 0.91
2-Pyrrolidone SCHEMBL3477689 0.91

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105001231-B A kind of preparation method of bilobalide K 成都百裕制药股份有限公司 2018-08-24 CN disclosed