Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.42 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | KDM5C | P41229 | 6/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 5/20 | 0.40 |
| ▸ | KDM4A | O75164 | 5/20 | 0.40 |
| ▸ | KDM6B | O15054 | 4/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295486 | 0.83 | MKNK1 (0.39) | KDM4EKDM4CP4HA1KDM5CKDM2A | |
| Hydrochloric Acid SCHEMBL19211726 | 0.81 | MKNK1 (0.38) | KDM4EKDM4CP4HA1KDM5CKDM2A | |
| SCHEMBL30415076 | 0.79 | PTPN11 (0.46) | KDM4EMAPTCYP4F2CYP4A11 | |
| SCHEMBL23416991 | 0.78 | KDM4E (0.58) | KDM4EUSP2HPGDHSD17B10P4HA1 | |
| SCHEMBL23416948 | 0.78 | KDM4E (0.42) | KDM4EUSP2HPGDHSD17B10P4HA1 | |
| SCHEMBL23416974 | 0.78 | KDM4E (0.42) | KDM4EUSP2HPGDHSD17B10P4HA1 | |
| SCHEMBL1219786 | 0.77 | EGLN1 (0.44) | KDM4EKDM4CKDM2AKDM3AKDM6B | |
| SCHEMBL23416932 | 0.74 | KMT2A (0.43) | KDM4EUSP2HPGDHSD17B10ALDH1A1 | |
| SCHEMBL9750144 | 0.74 | KDM4E (0.63) | KDM4EUSP2HPGDHSD17B10PIN1 | |
| SCHEMBL29933891 | 0.74 | HCAR2 (0.48) | KDM4EUSP2HPGDHSD17B10KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10849881-B2 | Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl | HOFFMANN-LA ROCHE INC. (US) | 2020-12-01 | — | — | US | disclosed |
| US-20200339570-A1 | BICYCLIC DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2020-10-29 | — | — | US | disclosed |
| CN-109952302-A | Muscarine M1 receptor forward direction allosteric modulators | 苏文生命科学有限公司 | 2019-06-28 | — | — | CN | disclosed |
| US-20180280352-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | HOFFMANN-LA ROCHE INC. (US) | 2018-10-04 | — | — | US | disclosed |
| US-20170050960-A1 | NEW BICYCLIC DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-02-23 | — | — | US | disclosed |
| WO-2016160677-A1 | COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION | ARISAN THERAPEUTICS INC. (US) | 2016-10-06 | — | — | WO | disclosed |
| EP-2427450-A1 | GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-2427448-A1 | Gpr 119 modulators | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128414-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010128425-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180280352-A1 | OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL | NPY1R, NPY2R, DECR1 | KDM4E 1536/4885USP2 2438/4885HPGD 3958/4885 |
| US-20170050960-A1 | NEW BICYCLIC DERIVATIVES | BICRA, CCNY, UQCRB | KDM4E 1849/4885USP2 4558/4885HPGD 1949/4885 |
| US-20200339570-A1 | BICYCLIC DERIVATIVES | CCNY, BICRA, UQCRB | KDM4E 1613/4885USP2 4634/4885HPGD 2461/4885 |
| US-10849881-B2 | Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl | NPY1R, NPY2R, DECR1 | KDM4E 1515/4885USP2 2441/4885HPGD 4077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.