Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | LMNA | P02545 | 4/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.82 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.82 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.67 |
| ▸ | HRH1 | P35367 | 5/20 | 0.67 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.67 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.67 |
| ▸ | DRD2 | P14416 | 3/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.67 |
| ▸ | DRD1 | P21728 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680979 | 0.90 | ALDH1A1 (1.00) | MAPTALDH1A1LMNAKDM4EPTK2B | |
| SCHEMBL30298406 | 0.88 | MAPT (0.64) | MAPTALDH1A1LMNAKDM4EPTK2B | |
| SCHEMBL10993180 | 0.85 | ALDH1A1 (0.64) | MAPTALDH1A1LMNAKDM4EPTK2B | |
| SCHEMBL10983074 | 0.85 | ALDH1A1 (0.64) | MAPTALDH1A1LMNAKDM4EPTK2B | |
| SCHEMBL3642723 | 0.81 | ALDH1A1 (0.72) | MAPTALDH1A1LMNAKDM4EPTK2B | |
| SCHEMBL1450332 | 0.81 | ALDH1A1 (0.82) | MAPTALDH1A1LMNAKDM4EPTK2B | |
| SCHEMBL7940135 | 0.80 | ALDH1A1 (1.00) | MAPTALDH1A1LMNAKDM4EPTK2B | |
| Imipramine SCHEMBL17004048 | 0.80 | SLC6A4 (1.00) | MAPTALDH1A1LMNAKDM4ESLC6A4 | |
| Imipramine SCHEMBL34282 | 0.80 | SLC6A4 (1.00) | MAPTALDH1A1LMNAKDM4ESLC6A4 | |
| SCHEMBL29531557 | 0.80 | ALDH1A1 (0.70) | MAPTALDH1A1LMNAKDM4EPTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108495855-A | Condesned thiazole and pyrimidine derivatives as MNK inhibitor | 生命弧度公司 | 2018-09-04 | — | — | CN | disclosed |