SCHEMBL28864262

SCHEMBL28864262

Cc1ccc(C2[CH]CC2(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 2/20 0.35
OPRK1 P41145 2/20 0.35
OPRL1 P41146 2/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
LMNA P02545 1/20 0.34
TSHR P16473 1/20 0.34
ALOX12 P18054 1/20 0.34
ACHE P22303 1/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
MAOA P21397 3/20 0.33
MAOB P27338 3/20 0.33
ADAM17 P78536 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PRCP P42785 1/20 0.33
HDAC4 P56524 1/20 0.33
CXCR3 P49682 1/20 0.32
SLC6A9 P48067 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28578003 1.00 OPRM1 (0.35) OPRM1OPRK1OPRL1SLC6A2SLC6A4
SCHEMBL28578431 0.82 KDM1A (0.46) SLC6A3LMNATSHRALOX12SMN1; SMN2
SCHEMBL28578218 0.75 HTR2C (0.37) OPRM1OPRK1OPRL1TSHRACHE
SCHEMBL28915480 0.68 POLB (0.36) LMNATSHRMEN1KMT2ASMN1; SMN2
SCHEMBL5998298 0.62 KDM1A (0.57) MAOAMAOBCACNA1FARPDE4A
SCHEMBL8845508 0.61 MAOB (0.45) MAOAMAOBCACNA1FARPDE4A
SCHEMBL11882335 0.61 MAOB (0.44) MAOAMAOBCACNA1FARPDE4A
P-Xylene SCHEMBL887790 0.60 ACHE (0.92) LMNATSHRALOX12ACHEMEN1
P-Xylene SCHEMBL17318276 0.60 ACHE (0.92) LMNATSHRALOX12ACHEMEN1
P-Xylene SCHEMBL11504018 0.60 ACHE (0.92) LMNATSHRALOX12ACHEMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108623425-A Method for constructing four-membered ring by visible light catalysis [2+2] reaction 中国科学院理化技术研究所 2018-10-09 CN disclosed