Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL28865870

C=CCc1cccc2sc(CCC)nc12.S.S.S.S.[SiH4]

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 5/20 0.36
TLR7 Q9NYK1 2/20 0.36
MEN1 O00255 4/20 0.34
KMT2A Q03164 4/20 0.34
GABRA1 P14867 1/20 0.33
GABRB2 P47870 1/20 0.33
ALDH1A1 P00352 5/20 0.31
MAPT P10636 4/20 0.31
USP2 O75604 2/20 0.31
PKM P14618 2/20 0.31
NPSR1 Q6W5P4 2/20 0.31
POLB P06746 1/20 0.31
ALOX15 P16050 1/20 0.31
HTT P42858 1/20 0.31
ATM Q13315 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
DHFR P00374 1/20 0.31
CYP3A4 P08684 2/20 0.31
IDO1 P14902 1/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrogen Sulfide SCHEMBL28264139 0.99 TLR8 (0.36) TLR8TLR7MEN1KMT2AGABRA1
SCHEMBL28243199 0.97 TLR8 (0.37) TLR8TLR7MEN1KMT2AGABRA1
SCHEMBL28360022 0.79 TLR8 (0.43) TLR8TLR7MEN1KMT2AALDH1A1
Formamide SCHEMBL5255988 0.78 TLR8 (0.41) TLR8TLR7MEN1KMT2AALDH1A1
SCHEMBL28532339 0.77 GABRA1 (0.39) MEN1KMT2AGABRA1GABRB2ALDH1A1
SCHEMBL28436383 0.74 GABRA1 (0.33) MEN1KMT2AGABRA1GABRB2ALDH1A1
SCHEMBL2360344 0.74 GABRA1 (0.46) MEN1KMT2AGABRA1GABRB2ALDH1A1
SCHEMBL3798167 0.74 GABRA1 (0.39) MEN1KMT2AGABRA1GABRB2ALDH1A1
SCHEMBL9412069 0.74 ALDH1A1 (0.51) MEN1KMT2AGABRA1GABRB2ALDH1A1
SCHEMBL2360291 0.74 GABRA1 (0.39) MEN1KMT2AGABRA1GABRB2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107108974-B Rubber composition for tire tread 横滨橡胶株式会社 2018-10-09 CN disclosed