Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | SELE | P16581 | 1/20 | 0.30 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2360291 | 0.81 | GABRA1 (0.39) | GABRA1GABRB2MEN1KMT2AL3MBTL1 | |
| SCHEMBL28532339 | 0.81 | GABRA1 (0.39) | GABRA1GABRB2MEN1KMT2AL3MBTL1 | |
| SCHEMBL9412069 | 0.81 | ALDH1A1 (0.51) | GABRA1GABRB2MEN1KMT2AL3MBTL1 | |
| SCHEMBL2360344 | 0.81 | GABRA1 (0.46) | GABRA1GABRB2MEN1KMT2AL3MBTL1 | |
| SCHEMBL11808159 | 0.77 | GABRA1 (0.36) | GABRA1GABRB2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3655835 | 0.77 | GABRA1 (0.39) | GABRA1GABRB2MEN1KMT2AL3MBTL1 | |
| SCHEMBL14696799 | 0.77 | PSMB8 (0.55) | GABRA1GABRB2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3655879 | 0.76 | GABRA1 (0.41) | GABRA1GABRB2MEN1KMT2AL3MBTL1 | |
| Hydrogen Sulfide SCHEMBL28865870 | 0.74 | TLR8 (0.36) | GABRA1GABRB2MEN1KMT2AALDH1A1 | |
| SCHEMBL3654540 | 0.73 | MEN1 (0.39) | GABRA1GABRB2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829580-B2 | Cyclic amine derivative having heteroaryl ring | SANKYO COMPANY, LTD. (JP) | 2010-11-09 | — | — | US | disclosed |
| US-20060270706-A1 | Cyclic amine derivative having heteroaryl ring | SANKYO COMPANY, LTD. (JP) | 2006-11-30 | — | — | US | disclosed |
| EP-1695962-A1 | CYCLIC AMINE DERIVATIVE HAVING HETEROARYL RING | Sankyo Company, Limited (JP) | 2006-08-30 | — | — | EP | disclosed |
| US-7012147-B2 | Enzyme inhibitors; chemical intermediates | SANKYO COMPANY, LIMITED (JP) | 2006-03-14 | — | — | US | disclosed |
| US-20060014965-A1 | Indoline derivative and process for producing the same | SANKYO COMPANY, LIMITED (JP) | 2006-01-19 | — | — | US | disclosed |
| US-20040058979-A1 | Indoline derivative and process for producing the same | SANKYO COMPANY, LIMITED (JP) | 2004-03-25 | — | — | US | disclosed |
| EP-1364942-A1 | INDOLINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | Sankyo Company, Limited (JP) | 2003-11-26 | — | — | EP | disclosed |
| EP-1152007-A1 | ETHER TYPE LIPID A1-CARBOXYLIC ACID ANALOGUES | Sankyo Company, Limited (JP) | 2001-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270706-A1 | Cyclic amine derivative having heteroaryl ring | F12, F2, H1-3 | GABRA1 1864/4885GABRB2 3504/4885MEN1 755/4885 |
| US-20060014965-A1 | Indoline derivative and process for producing the same | ACAT2, ACAT1, INMT | GABRA1 4192/4885GABRB2 3993/4885MEN1 2291/4885 |
| US-20040058979-A1 | Indoline derivative and process for producing the same | ACAT2, ACAT1, INMT | GABRA1 4192/4885GABRB2 3993/4885MEN1 2291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.