Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Testolactone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 known ✓ | P11511 | 15/20 | 0.84 |
| ▸ | LMNA | P02545 | 2/20 | 0.84 |
| ▸ | MAPT | P10636 | 2/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Testolactone SCHEMBL4053 | 0.92 | CYP19A1 (1.00) | CYP19A1LMNAMAPTCYP3A4 | |
| Testolactone SCHEMBL2300061 | 0.92 | CYP19A1 (1.00) | CYP19A1LMNAMAPTCYP3A4 | |
| Testolactone SCHEMBL5083091 | 0.89 | CYP19A1 (0.89) | CYP19A1LMNAMAPTCYP3A4 | |
| SCHEMBL25992396 | 0.81 | CYP19A1 (0.79) | CYP19A1LMNAMAPTCYP3A4 | |
| Propionic Acid SCHEMBL29224763 | 0.79 | CYP19A1 (0.85) | CYP19A1LMNAMAPTCYP3A4 | |
| Testosterone Propionate SCHEMBL9384323 | 0.79 | LMNA (0.70) | CYP19A1LMNAMAPTCYP3A4 | |
| Testolactone SCHEMBL28285815 | 0.78 | CYP19A1 (0.68) | CYP19A1LMNAMAPTCYP3A4 | |
| SCHEMBL8980363 | 0.77 | CYP19A1 (0.72) | CYP19A1LMNAMAPTCYP3A4 | |
| Testolactone SCHEMBL13732511 | 0.77 | CYP19A1 (0.64) | CYP19A1LMNAMAPTCYP3A4 | |
| SCHEMBL23691780 | 0.75 | CYP19A1 (0.67) | CYP19A1LMNAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087664-A | IL-2R beta gamma c binding compounds | 麦地金公司 | 2022-09-20 | — | — | CN | disclosed |