Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | MST1R | Q04912 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13370726 | 0.77 | NTRK2 (0.43) | NTRK2CLK4DYRK1BTYRO3JAK2 | |
| SCHEMBL30094647 | 0.76 | NTRK2 (0.51) | NTRK2CLK4DYRK1BTYRO3JAK2 | |
| SCHEMBL2042249 | 0.76 | NTRK2 (0.51) | NTRK2CLK4DYRK1BTYRO3JAK2 | |
| SCHEMBL7895778 | 0.76 | CLK4 (0.51) | NTRK2CLK4DYRK1BTYRO3JAK2 | |
| SCHEMBL27085978 | 0.76 | NTRK2 (0.51) | NTRK2CLK4DYRK1BTYRO3JAK2 | |
| SCHEMBL27951808 | 0.75 | PBRM1 (0.50) | GRM5 | |
| SCHEMBL28277152 | 0.74 | DRD2 (0.35) | TYK2DRD2 | |
| SCHEMBL23565694 | 0.73 | CLK4 (0.49) | NTRK2CLK4DYRK1BTYRO3JAK2 | |
| SCHEMBL29902256 | 0.73 | CLK4 (0.49) | NTRK2CLK4DYRK1BTYRO3JAK2 | |
| SCHEMBL28115873 | 0.73 | NTRK2 (0.49) | NTRK2CLK4DYRK1BTYRO3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113563245-A | Substituted pyrrolidine compounds and application thereof in medicines | 广东东阳光药业有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-109311867-A | Conjugate comprising RIPK2 inhibitor | 葛兰素史克知识产权开发有限公司 | 2019-02-05 | — | — | CN | disclosed |