SCHEMBL7895778

SCHEMBL7895778

CCc1ccc2c(c1)C(=O)NC2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK4 Q9HAZ1 3/20 0.51
NTRK2 Q16620 2/20 0.51
DYRK1B Q9Y463 2/20 0.51
TYRO3 Q06418 1/20 0.51
KDR P35968 2/20 0.50
NTRK1 P04629 2/20 0.50
FLT3 P36888 2/20 0.50
GSK3B P49841 2/20 0.50
JAK2 O60674 1/20 0.50
MET P08581 1/20 0.50
FGFR1 P11362 1/20 0.50
PRKACA P17612 1/20 0.50
MAP2K2 P36507 1/20 0.50
MAP2K1 Q02750 1/20 0.50
MST1R Q04912 1/20 0.50
NTRK3 Q16288 1/20 0.50
CAMK1D Q8IU85 1/20 0.50
FYN P06241 1/20 0.50
CA12 O43570 1/20 0.48
CA9 Q16790 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7901539 0.86 CLK4 (0.49) CLK4NTRK2DYRK1BTYRO3KDR
SCHEMBL8162850 0.83 PARP10 (0.63) SMN1; SMN2NPC1ALDH1A1LMNAMAPT
SCHEMBL27085978 0.82 NTRK2 (0.51) CLK4NTRK2DYRK1BTYRO3KDR
SCHEMBL30094647 0.82 NTRK2 (0.51) CLK4NTRK2DYRK1BTYRO3KDR
SCHEMBL2042249 0.82 NTRK2 (0.51) CLK4NTRK2DYRK1BTYRO3KDR
SCHEMBL12194607 0.81 CLK4 (0.47) CLK4NTRK2DYRK1BTYRO3KDR
SCHEMBL20625609 0.81 CLK4 (0.47) CLK4NTRK2DYRK1BTYRO3KDR
SCHEMBL12464716 0.80 PARP10 (0.51) SMN1; SMN2NPC1ALDH1A1LMNAMAPT
SCHEMBL23565694 0.79 CLK4 (0.49) CLK4NTRK2DYRK1BTYRO3KDR
SCHEMBL29902256 0.79 CLK4 (0.49) CLK4NTRK2DYRK1BTYRO3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230286970-A1 NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS ITALFARMACO SPA (IT) 2023-09-14 US disclosed
US-20230183214-A1 IL4I1 INHIBITORS AND METHODS OF USE MERCK SHARP & DOHME LLC 2023-06-15 US disclosed
US-20230183214-A1 IL4I1 INHIBITORS AND METHODS OF USE MERCK SHARP & DOHME LLC 2023-06-15 US disclosed
US-11572367-B2 Antiviral heterocyclic compounds ENANTA PHARMACEUTICALS, INC. (US) 2023-02-07 US disclosed
US-11420976-B2 Heterocyclic compounds as anti-viral agents ENANTA PHARMACEUTICALS, INC. (US) 2022-08-23 US disclosed
WO-2021226003-A1 IL4I1 INHIBITORS AND METHODS OF USE MERCK SHARP & DOHME CORP. (US) 2021-11-11 WO disclosed
US-20210238188-A1 HETEROCYCLIC COMPOUNDS AS ANTI-VIRAL AGENTS ENANTA PHARMACEUTICALS, INC. 2021-08-05 US disclosed
US-20210009555-A1 THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2021-01-14 US disclosed
US-10807994-B2 Heterocyclic compounds and uses thereof NUVATION BIO INC. (US) 2020-10-20 US disclosed
US-20190106427-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) 2019-04-11 US disclosed
US-20120277192-A1 AMINOPYRIMIDINES AS SYK INHIBITORS MERCK SHARP & DOHME LLC 2012-11-01 US disclosed
US-8039506-B2 Bicyclic lactam factor VIIa inhibitors useful as anticoagulants BRISTOL-MYERS SQUIBB COMPANY (US) 2011-10-18 US disclosed
US-20110245205-A1 AMINOPYRIMIDINES AS SYK INHIBITORS MERCK SHARP & DOHME LLC 2011-10-06 US disclosed
US-20110135650-A1 MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS MERCK SHARP & DOHME LLC 2011-06-09 US disclosed
US-20100173899-A1 DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2010-07-08 US disclosed
WO-2010065717-A1 MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2010-06-10 WO disclosed
US-7705004-B2 Protein kinase inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2010-04-27 US disclosed
US-20100041664-A1 BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS BRISTOL-MYERS SQUIBB COMPANY 2010-02-18 US disclosed
US-20090054425-A1 PROTEIN KINASE INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2009-02-26 US disclosed
WO-2008079836-A2 MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245205-A1 AMINOPYRIMIDINES AS SYK INHIBITORS SYK, BTK, LCK CLK4 2976/4885NTRK2 3900/4885DYRK1B 311/4885
US-20210009555-A1 THERAPEUTIC COMPOUNDS HAVCR2, SARS1, RPL35 CLK4 4768/4885NTRK2 4324/4885DYRK1B 4883/4885
US-20110135650-A1 MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS SERPINC1, F9, F8 CLK4 4605/4885NTRK2 4829/4885DYRK1B 4793/4885
US-20210238188-A1 HETEROCYCLIC COMPOUNDS AS ANTI-VIRAL AGENTS VIP, ACE, FURIN CLK4 4658/4885NTRK2 3989/4885DYRK1B 4861/4885
US-20100041664-A1 BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS F7, F8, F9 CLK4 1808/4885NTRK2 4569/4885DYRK1B 4261/4885
US-20230183214-A1 IL4I1 INHIBITORS AND METHODS OF USE IL4I1, IL4, IL2 CLK4 1290/4885NTRK2 2625/4885DYRK1B 4829/4885
US-20230286970-A1 NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS HDAC6, HDAC1, HDAC3 CLK4 2409/4885NTRK2 2514/4885DYRK1B 2352/4885
US-20090054425-A1 PROTEIN KINASE INHIBITORS SYK, JAK2, BTK CLK4 965/4885NTRK2 2015/4885DYRK1B 197/4885
US-11420976-B2 Heterocyclic compounds as anti-viral agents VIP, ACE, FURIN CLK4 4658/4885NTRK2 3989/4885DYRK1B 4861/4885
US-10807994-B2 Heterocyclic compounds and uses thereof WEE1, WEE2, CCNE1 CLK4 2986/4885NTRK2 4601/4885DYRK1B 3720/4885
US-11572367-B2 Antiviral heterocyclic compounds ACE, HPRT1, ACE2 CLK4 4598/4885NTRK2 3146/4885DYRK1B 4732/4885
US-20120277192-A1 AMINOPYRIMIDINES AS SYK INHIBITORS SYK, BTK, LCK CLK4 2976/4885NTRK2 3900/4885DYRK1B 311/4885
US-20190106427-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF WEE1, WEE2, NME1 CLK4 2308/4885NTRK2 4493/4885DYRK1B 3205/4885
US-20100173899-A1 DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS F11, TFPI, SERPINC1 CLK4 1985/4885NTRK2 1941/4885DYRK1B 966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.