Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.36 |
| ▸ | KLK1 | P06870 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825963 | 0.85 | KLKB1 (0.38) | KLKB1KLK1 | |
| SCHEMBL28047249 | 0.81 | KLKB1 (0.37) | KLKB1KLK1POLBNPSR1 | |
| SCHEMBL27735785 | 0.68 | — | — | |
| SCHEMBL9752787 | 0.67 | POLB (0.63) | KLKB1KLK1POLBNPSR1 | |
| SCHEMBL27528515 | 0.67 | GLS (0.32) | — | |
| SCHEMBL16881558 | 0.66 | POLB (0.54) | KLKB1KLK1POLBNPSR1 | |
| SCHEMBL28029165 | 0.66 | — | — | |
| SCHEMBL27518484 | 0.65 | FFAR1 (0.38) | — | |
| SCHEMBL27520808 | 0.65 | MDM4 (0.33) | — | |
| SCHEMBL17229327 | 0.65 | POLB (0.50) | KLKB1KLK1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311847-A | PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | 卡尔维斯塔制药有限公司 | 2019-02-05 | — | — | CN | disclosed |