Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA6 | P23280 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA3 | P07451 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL28903626 | 0.93 | GSR (0.41) | GSRGRIK1GRIK2GRM1GRM2 | |
| Aspartic Acid SCHEMBL31555109 | 0.85 | GSR (0.64) | GSRGRIK1GRIK2GRM1GRM2 | |
| Aspartic Acid SCHEMBL6941414 | 0.84 | GRIK1 (0.50) | GSRGRIK1GRIK2GRM1GRM2 | |
| Aspartic Acid SCHEMBL27200583 | 0.83 | GRIK1 (0.42) | GSRGRIK1GRIK2GRM1GRM2 | |
| Aspartic Acid SCHEMBL4159270 | 0.83 | GSR (0.61) | GSRGRIK1GRIK2GRM1GRM2 | |
| Aspartic Acid SCHEMBL27526284 | 0.83 | GSR (0.61) | GSRGRIK1GRIK2GRM1GRM2 | |
| Aspartic Acid SCHEMBL3230 | 0.82 | — | — | |
| Aspartic Acid SCHEMBL1526976 | 0.82 | GRIK1 (0.56) | GSRGRIK1GRIK2GRM1GRM2 | |
| D-Aspartate SCHEMBL145539 | 0.82 | — | — | |
| Aspartic Acid SCHEMBL11065189 | 0.82 | GRIK1 (0.56) | GSRGRIK1GRIK2GRM1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115286738-A | Polyacrylic acid aspartate resin and preparation method thereof | 佛山市万化科技有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-102971002-B | Delivery of nucleic acids composition and carrier compositions, pharmaceutical composition and nucleic acid delivery method using it | 国立大学法人东京大学 | 2019-04-05 | — | — | CN | disclosed |