Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.49 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17925886 | 0.98 | MEN1 (0.57) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL2096025 | 0.84 | MAPT (0.75) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL30695893 | 0.84 | HDAC8 (0.62) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL2093458 | 0.84 | HDAC8 (0.62) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL30130682 | 0.84 | MAPT (0.75) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL23213561 | 0.83 | MEN1 (0.50) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL2093508 | 0.81 | MAPT (0.57) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL7541399 | 0.81 | MEN1 (0.49) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL28923619 | 0.81 | MEN1 (0.49) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL22678507 | 0.80 | SMN1; SMN2 (0.56) | MAPTMEN1KMT2AHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207515-B | Pyrazine compounds for the treatment of infectious diseases | 豪夫迈·罗氏有限公司 | 2019-05-28 | — | — | CN | disclosed |