SCHEMBL28874167

SCHEMBL28874167

COc1cc(C)c(-n2cnc(C)c2C)c(C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
HPGD P15428 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
HIF1A Q16665 1/20 0.39
HSD17B10 Q99714 1/20 0.39
GABRG2 P18507 1/20 0.35
GABRB3 P28472 1/20 0.35
GABRA5 P31644 1/20 0.35
FGFR1 P11362 3/20 0.33
HTT P42858 2/20 0.33
MAPK1 P28482 1/20 0.33
MAPK10 P53779 1/20 0.33
NCOA1 Q15788 1/20 0.33
NCOA3 Q9Y6Q9 1/20 0.33
CRHR1 P34998 2/20 0.33
CYP19A1 P11511 1/20 0.33
NQO2 P16083 1/20 0.33
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28874174 0.98 ALDH1A1 (0.38) ALDH1A1HPGDCYP1A2CYP2D6HIF1A
SCHEMBL29844064 0.81 ALDH1A1 (0.43) ALDH1A1HPGDCYP1A2CYP2D6HIF1A
SCHEMBL6756743 0.73 ALDH1A1 (0.43) ALDH1A1HPGDCYP1A2CYP2D6HIF1A
SCHEMBL22114467 0.72 FGFR1 (0.59) ALDH1A1HPGDCYP1A2CYP2D6HIF1A
SCHEMBL11058522 0.71 FGFR1 (0.40) ALDH1A1FGFR1CRHR1CYP19A1NQO2
SCHEMBL6754345 0.68 MEN1 (0.41) ALDH1A1HPGDCYP1A2CYP2D6HIF1A
SCHEMBL20697961 0.67 PDE2A (0.44) ALDH1A1HPGDCYP1A2CYP2D6HIF1A
SCHEMBL31226668 0.66 CYP3A4 (0.46) ALDH1A1HPGDHSD17B10HTTMAPK1
SCHEMBL15826889 0.65 ALDH1A1 (0.46) ALDH1A1HPGDCYP1A2CYP2D6HIF1A
Hydrochloric Acid SCHEMBL30081990 0.64 ALDH1A1 (0.30) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115286547-B Method for synthesizing aryl benzyl thioether compound 苏州大学 2023-11-03 CN disclosed
CN-115286547-A Method for synthesizing aryl benzyl sulfide compound 苏州大学 2022-11-04 CN disclosed
CN-115286547-A Method for synthesizing aryl benzyl sulfide compound 苏州大学 2022-11-04 CN disclosed