Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11052944 | 0.84 | CRHR1 (0.38) | LCKKITSRCXDHALDH1A1 | |
| SCHEMBL11059092 | 0.82 | HCAR1 (0.35) | KMT2AALDH1A1MAPT | |
| SCHEMBL11052581 | 0.78 | HCAR1 (0.48) | FGFR1XDHKMT2AALDH1A1 | |
| SCHEMBL11057681 | 0.76 | APLNR (0.39) | FGFR1CYP19A1NQO2KMT2AALDH1A1 | |
| SCHEMBL11061906 | 0.75 | CDK4 (0.36) | FGFR1FGFR2FGFR4FGFR3LCK | |
| SCHEMBL11056825 | 0.75 | CRHR1 (0.37) | LCKKITSRCCRHR1 | |
| SCHEMBL11052927 | 0.75 | HCAR1 (0.33) | LCKKITSRCGRM1P2RX7 | |
| SCHEMBL11055534 | 0.72 | LCK (0.36) | LCKKITSRCCRHR1 | |
| SCHEMBL11061649 | 0.71 | GABRB3 (0.40) | LCKKITSRC | |
| SCHEMBL28874167 | 0.71 | ALDH1A1 (0.39) | FGFR1CYP19A1NQO2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |