Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.44 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.60 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.45 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL28676897 | 1.00 | SLC7A5 (0.60) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL3513723 | 0.91 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL1921853 | 0.91 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL530008 | 0.91 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL1920944 | 0.91 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL3485478 | 0.91 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL571284 | 0.91 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL21925058 | 0.91 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL3303402 | 0.91 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL11404585 | 0.90 | SLC7A5 (0.57) | SLC7A5ITGB3ITGA2BGSRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110183515-B | Polypeptide for PTP1B detection and fluorescent probe containing polypeptide | 浙江中医药大学 | 2020-09-29 | — | — | CN | disclosed |
| CN-110183515-A | It is a kind of for PTP1B detection polypeptide and include the fluorescence probe of the polypeptide | 浙江中医药大学 | 2019-08-30 | — | — | CN | disclosed |
| CN-110183515-A | It is a kind of for PTP1B detection polypeptide and include the fluorescence probe of the polypeptide | 浙江中医药大学 | 2019-08-30 | — | — | CN | disclosed |