SCHEMBL28875552

SCHEMBL28875552

N#Cc1ccc(-c2ccsc2C=O)cc1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 2/20 0.51
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
MMP3 P08254 2/20 0.37
GAA P10253 1/20 0.36
CYP11B2 P19099 2/20 0.35
XDH P47989 2/20 0.35
SLC22A12 Q96S37 2/20 0.35
KIF11 P52732 2/20 0.34
HDAC2 Q92769 1/20 0.34
MMP2 P08253 1/20 0.34
PRF1 P14222 1/20 0.34
AR P10275 1/20 0.34
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
STS P08842 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3975326 0.77 PTGS1 (0.37) PTGS1
SCHEMBL3722270 0.77 PTGS1 (0.60) PTGS1
SCHEMBL1829790 0.77 PTGS2 (0.45) PTGS1MMP3GAAMMP2
SCHEMBL16049525 0.77 PTGS1 (0.40) PTGS1CA12CA9XDH
SCHEMBL6822436 0.77 PTGS1 (0.40) PTGS1CA12CA2CA9
SCHEMBL2461016 0.76 BCAT2 (0.47) PTGS1
SCHEMBL2033018 0.76 PTGS1 (0.38) PTGS1CA12CA1CA2CA9
SCHEMBL30940239 0.75 APP (0.41) PTGS1
SCHEMBL9696347 0.74 PRKDC (0.41) PTGS1
SCHEMBL11705358 0.72 PTGS1 (0.37) PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110016011-A Amide derivatives and its medical usage 泰州华元医药科技有限公司 2019-07-16 CN disclosed