SCHEMBL2887574

SCHEMBL2887574

CO[Si](OC)(OC)C(C)c1cccc(C(C)Br)c1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.33
HDAC8 Q9BY41 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL574711 0.90 HDAC4 (0.38) HDAC4HDAC8
SCHEMBL2883565 0.82 SLC22A1 (0.32) HDAC4HDAC8
SCHEMBL927965 0.82 ESR1 (0.30)
SCHEMBL8897527 0.81 HDAC4 (0.37) HDAC4HDAC8
SCHEMBL927531 0.81 HDAC4 (0.33) HDAC4HDAC8
SCHEMBL2883850 0.81 HDAC4 (0.33) HDAC4HDAC8
SCHEMBL926550 0.80
SCHEMBL140535 0.77 TRPA1 (0.39)
SCHEMBL27849338 0.77 AOC3 (0.45)
SCHEMBL2888934 0.77 CYP4F2 (0.38) HDAC4HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2207782-A2 HALO-FUNCTIONAL SILANE, PROCESS FOR ITS PREPARATION, RUBBER COMPOSITION CONTAINING SAME AND ARTICLES MANUFACTURED THEREFROM Momentive Performance Materials Inc. (US) 2010-07-21 EP claimed
US-7625965-B2 Rubber composition, process of preparing same and articles made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2009-12-01 US claimed
EP-2121349-A1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM Momentive Performance Materials Inc. (US) 2009-11-25 EP claimed
WO-2009058373-A2 HALO-FUNCTIONAL SILANE, PROCESS FOR ITS PREPARATION, RUBBER COMPOSITION CONTAINING SAME AND ARTICLES MANUFACTURED THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2009-05-07 WO claimed
US-20090111923-A1 Halo-functional silane, process for its preparation, rubber composition containing same and articles manufactured therefrom MOMENTIVE PERFORMANCE MATERIALS INC. 2009-04-30 US claimed
WO-2008097587-A1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC (US) 2008-08-14 WO claimed
US-20080194746-A1 Rubber composition, process of preparing same and articles made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. 2008-08-14 US claimed
EP-2708546-B1 Halo-Functional Silane, process for its preparation, rubber composition containing same and articles manufactured therefrom MOMENTIVE PERFORMANCE MAT INC (US) 2016-01-06 EP disclosed
EP-2708546-A1 Halo-Functional Silane, process for its preparation, rubber composition containing same and articles manufactured therefrom Momentive Performance Materials Inc. (US) 2014-03-19 EP disclosed
EP-2207782-B1 HALO-FUNCTIONAL SILANE, PROCESS FOR ITS PREPARATION, RUBBER COMPOSITION CONTAINING SAME AND ARTICLES MANUFACTURED THEREFROM MOMENTIVE PERFORMANCE MAT INC (US) 2014-02-26 EP disclosed
EP-2121349-B1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MAT INC (US) 2010-11-17 EP disclosed
US-7816435-B2 Halo-functional silane, process for its preparation, rubber composition containing same and articles manufactured therefrom MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2010-10-19 US disclosed
EP-2207782-A2 HALO-FUNCTIONAL SILANE, PROCESS FOR ITS PREPARATION, RUBBER COMPOSITION CONTAINING SAME AND ARTICLES MANUFACTURED THEREFROM Momentive Performance Materials Inc. (US) 2010-07-21 EP disclosed
US-7625965-B2 Rubber composition, process of preparing same and articles made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2009-12-01 US disclosed
EP-2121349-A1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM Momentive Performance Materials Inc. (US) 2009-11-25 EP disclosed
WO-2009058373-A2 HALO-FUNCTIONAL SILANE, PROCESS FOR ITS PREPARATION, RUBBER COMPOSITION CONTAINING SAME AND ARTICLES MANUFACTURED THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2009-05-07 WO disclosed
US-20090111923-A1 Halo-functional silane, process for its preparation, rubber composition containing same and articles manufactured therefrom MOMENTIVE PERFORMANCE MATERIALS INC. 2009-04-30 US disclosed
WO-2008097587-A1 RUBBER COMPOSITION, PROCESS OF PREPARING SAME AND ARTICLES MADE THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC (US) 2008-08-14 WO disclosed
US-20080194746-A1 Rubber composition, process of preparing same and articles made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. 2008-08-14 US disclosed