SCHEMBL8897527

SCHEMBL8897527

CC(Br)c1cccc(C(C)Br)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 2/20 0.37
HDAC8 Q9BY41 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MDM4 O15151 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
TP53 P04637 1/20 0.37
CYP3A4 P08684 1/20 0.37
MAPT P10636 1/20 0.37
TYR P14679 1/20 0.37
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
ALOX12 P18054 1/20 0.37
CA5A P35218 1/20 0.37
HTT P42858 1/20 0.37
MDM2 Q00987 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CA9 Q16790 1/20 0.37
HDAC2 Q92769 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28434776 0.92 HDAC4 (0.47) HDAC4HDAC8KDM4EMDM4ALDH1A1
SCHEMBL28019458 0.90 PGK1 (0.39) HDAC4HDAC8KDM4EMDM4ALDH1A1
SCHEMBL1539046 0.88 PGK1 (0.38) HDAC4HDAC8KDM4EMDM4ALDH1A1
SCHEMBL30549337 0.85 ALDH1A1 (0.46) ALDH1A1CYP3A4SMN1; SMN2
SCHEMBL4103278 0.85 ALDH1A1 (0.46) ALDH1A1CYP3A4SMN1; SMN2
SCHEMBL30647112 0.85 ACHE (0.50) ALDH1A1TP53CYP3A4MAPTHPGD
SCHEMBL30647223 0.85 ACHE (0.50) ALDH1A1TP53CYP3A4MAPTHPGD
SCHEMBL1812638 0.85 ACHE (0.50) ALDH1A1TP53CYP3A4MAPTHPGD
SCHEMBL626360 0.83 PNMT (0.44) ALDH1A1HPGDADRB1
SCHEMBL508509 0.83 ACHE (0.44) HDAC4CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102898470-B Novel organic phosphine compound and preparation method and application thereof UNIV BEIJING NORMAL 2014-12-10 CN claimed
WO-2025107460-A1 DEUTERATED INDOLE UREA COMPOUND AND MEDICAL USE THEREOF 重庆中国药科大学创新研究院 2025-05-30 WO disclosed
CN-117777004-A Deuterated indolyl urea compound and medical application thereof 重庆中国药科大学创新研究院 2024-03-29 CN disclosed
CN-114956933-A Marker containing isotope oxygen atom and preparation method and application thereof 清华大学 2022-08-30 CN disclosed
CN-111517902-B Aerobic oxidation system containing sulfinic acid, sulfonic acid or derivatives thereof and photo-oxidation promoting method thereof 清华大学 2022-06-14 CN disclosed
CN-111517902-A Aerobic oxidation system containing sulfinic acid, sulfonic acid or derivatives thereof and photo-oxidation promoting method thereof 清华大学 2020-08-11 CN disclosed
WO-2020155595-A1 AEROBIC OXIDATION SYSTEM CONTAINING SULFINIC ACID, SULFONIC ACID OR DERIVATIVES THEREOF AND PHOTOCATALYTIC OXIDATION METHOD THEREFOR 清华大学 2020-08-06 WO disclosed
CN-105555766-A Aminomethyl-biaryl derivatives as complement factor D inhibitors and uses thereof NOVARTIS AG 2016-05-04 CN disclosed
CN-105555911-A Electrochromic single and two-core viologens and optical articles containing them ESSILOR INT CIE GENERALE D'OPTIQUE 2016-05-04 CN disclosed
CN-102256989-B The anionic conjugates of glycosylated bacterial metabolite GLYCAN BIOSCIENCES PTY LTD. (US) 2016-01-06 CN disclosed
CN-102898470-B Novel organic phosphine compound and preparation method and application thereof UNIV BEIJING NORMAL 2014-12-10 CN disclosed
CN-103635489-A Plasma prekallikrein binding proteins DYAX CORP 2014-03-12 CN disclosed
EP-0531715-B1 Process for producing alcohols and ketones SUMITOMO CHEMICAL CO (JP) 1997-11-05 EP disclosed
US-5426237-A Oxidation of straight, branched or cyclic alkanes and benzene derivatives in presence of transition metal catalyst and aldehyde SUMITOMO CHEMICAL CO., LTD. (JP) 1995-06-20 US disclosed
EP-0531715-A1 Process for producing alcohols and ketones SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-03-17 EP disclosed
US-4223172-A DEHYDROGENATION HALOGENATIVE WITH PALLADIUM-PHOSPHINE COMPLEX CATALYST GULF RESEARCH & DEVELOPMENT COMPANY (US) 1980-09-16 US disclosed
US-4128556-A COMPLEXING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1978-12-05 US disclosed
US-3939084-A Functional fluid compositions containing substituted pyrimidines MONSANTO COMPANY (US) 1976-02-17 US disclosed