Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.77 |
| ▸ | JAK3 | P52333 | 7/20 | 0.77 |
| ▸ | TYK2 | P29597 | 3/20 | 0.77 |
| ▸ | JAK1 | P23458 | 6/20 | 0.62 |
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28875987 | 0.91 | JAK2 (0.76) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL28876014 | 0.90 | JAK3 (0.77) | JAK2JAK3TYK2JAK1SMG1 | |
| SCHEMBL29813581 | 0.87 | JAK2 (1.00) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL28875975 | 0.87 | JAK2 (1.00) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL28875991 | 0.84 | JAK3 (0.77) | JAK2JAK3TYK2JAK1SCN9A | |
| SCHEMBL28394053 | 0.84 | JAK3 (0.55) | JAK2JAK3TYK2JAK1SCN9A | |
| SCHEMBL28387824 | 0.84 | JAK3 (0.55) | JAK2JAK3TYK2JAK1SCN9A | |
| SCHEMBL28382437 | 0.81 | JAK3 (0.52) | JAK2JAK3TYK2JAK1SCN9A | |
| SCHEMBL28383508 | 0.81 | JAK3 (0.52) | JAK2JAK3TYK2JAK1SCN9A | |
| SCHEMBL28875997 | 0.80 | JAK2 (0.75) | JAK2JAK3TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |