Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.77 |
| ▸ | JAK2 | O60674 | 7/20 | 0.77 |
| ▸ | JAK1 | P23458 | 5/20 | 0.77 |
| ▸ | TYK2 | P29597 | 4/20 | 0.77 |
| ▸ | EGFR | P00533 | 4/20 | 0.56 |
| ▸ | BTK | Q06187 | 6/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28875997 | 0.90 | JAK2 (0.75) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL28876006 | 0.90 | JAK2 (0.77) | JAK3JAK2JAK1TYK2SMG1 | |
| SCHEMBL28876009 | 0.87 | JAK2 (1.00) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL29813541 | 0.87 | JAK2 (1.00) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL15637731 | 0.86 | JAK2 (0.80) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL17071413 | 0.86 | JAK2 (0.88) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL17071335 | 0.86 | JAK3 (0.79) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL17071334 | 0.86 | JAK3 (0.79) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL17071342 | 0.84 | JAK3 (0.75) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL28875996 | 0.83 | JAK3 (0.76) | JAK3JAK2JAK1TYK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |