Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.75 |
| ▸ | JAK3 | P52333 | 12/20 | 0.75 |
| ▸ | JAK1 | P23458 | 8/20 | 0.75 |
| ▸ | TYK2 | P29597 | 6/20 | 0.75 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28876014 | 0.90 | JAK3 (0.77) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL28875987 | 0.89 | JAK2 (0.76) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL28875992 | 0.86 | JAK2 (1.00) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL29813742 | 0.86 | JAK2 (1.00) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL28876026 | 0.82 | JAK3 (0.75) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL28556666 | 0.81 | JAK2 (0.77) | JAK2JAK3JAK1TYK2PDGFRB | |
| SCHEMBL17287879 | 0.80 | JAK2 (0.56) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL28876006 | 0.80 | JAK2 (0.77) | JAK2JAK3JAK1TYK2 | |
| Morpholine SCHEMBL28330189 | 0.79 | JAK2 (0.70) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL15637731 | 0.78 | JAK2 (0.80) | JAK2JAK3JAK1TYK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |