Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 4/20 | 0.31 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28877904 | 0.81 | MGMT (0.40) | MTORPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29974131 | 0.81 | MGMT (0.40) | MTORPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28957972 | 0.79 | ADORA2A (0.47) | PIK3CGDHFRADORA1ADORA2A | |
| SCHEMBL16076591 | 0.71 | PTGES (0.38) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL29939288 | 0.69 | KDM4E (0.50) | PIK3CAPIK3CDPIK3CBDAO | |
| SCHEMBL557830 | 0.69 | KDM4E (0.50) | PIK3CAPIK3CDPIK3CBDAO | |
| SCHEMBL30607712 | 0.67 | DPP4 (0.40) | PIK3CAPIK3CDPIK3CBPDE4APDE4B | |
| SCHEMBL16463518 | 0.65 | CSNK1A1 (0.61) | PIK3CGMTORPDE4APDE4DDHFR | |
| SCHEMBL25324910 | 0.64 | MAT2A (0.37) | PIK3CAPIK3CDPIK3CBPDE4APDE4B | |
| SCHEMBL9158351 | 0.64 | DAO (0.42) | DAOPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115141202-A | Pyrimidopyrazinone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-04 | — | — | CN | disclosed |