Sugi Predict

Sugi Predict / Compounds / SCHEMBL2887856

SCHEMBL2887856

SCHEMBL2887856

Cc1cc(Cn2cc(C(F)(F)F)nc2C(F)(F)F)ccc1N

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SKP2 Q13309 1/20 0.37
▸ ADORA3 P0DMS8 1/20 0.34
▸ ADORA2A P29274 1/20 0.34
▸ ADORA2B P29275 1/20 0.34
▸ ADORA1 P30542 1/20 0.34
▸ AGTR2 P50052 3/20 0.33
▸ PRMT6 Q96LA8 1/20 0.33
▸ TLR7 Q9NYK1 1/20 0.33
▸ BACE1 P56817 1/20 0.33
▸ HSP90AA1 P07900 1/20 0.33
▸ HSP90AB1 P08238 1/20 0.33
▸ DGAT1 O75907 1/20 0.32
▸ SOS1 Q07889 1/20 0.32
▸ S100B P04271 1/20 0.32
▸ SDHB P21912 2/20 0.32
▸ PTGS1 P23219 1/20 0.32
▸ PTGS2 P35354 1/20 0.32
▸ MAPT P10636 2/20 0.32
▸ LMNA P02545 1/20 0.32
▸ HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2891447 0.76 CYP3A4 (0.43) SKP2ADORA3ADORA2AADORA2BADORA1
SCHEMBL13335218 0.76 ADORA3 (0.39) SKP2ADORA3ADORA2AADORA2BADORA1
SCHEMBL1832384 0.74 ADORA3 (0.38) SKP2ADORA3ADORA2AADORA2BADORA1
SCHEMBL12402161 0.73 HPGD (0.46) SKP2MAPTLMNAKDM4E
SCHEMBL2884224 0.72 SKP2 (0.38) SKP2ADORA3ADORA2AADORA2BADORA1
SCHEMBL1831039 0.72 GRIA2 (0.47) SKP2ADORA3ADORA2AADORA2BADORA1
SCHEMBL1833654 0.71 ADORA3 (0.36) SKP2ADORA3ADORA2AADORA2BADORA1
SCHEMBL1838818 0.71 ADORA3 (0.36) SKP2ADORA3ADORA2AADORA2BADORA1
SCHEMBL1826287 0.71 SKP2 (0.41) SKP2TLR7HSP90AA1HSP90AB1S100B
SCHEMBL2883869 0.69 ADORA3 (0.34) SKP2ADORA3ADORA2AADORA2BADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100130743-A1 HETEROCYCLE-SUBSTITUTED, N-PHENYL-PHTHALAMIDE DERIVATIVES, RELATED COMPOUNDS AND THEIR USE AS INSECTICIDES BAYER CROPSCIENCE AG (DE) 2010-05-27 — — US disclosed
US-7674807-B2 Heterocycle-substituted n-phenyl-phthalamide derivatives, related compounds and their use as insecticides BAYER CROPSCIENCE AG (DE) 2010-03-09 — — US disclosed
US-20070299085-A1 N1-((Pyrazol-1-Ymethyl)-2-Methylphenyl)-Phatalamide Derivatives And Related Compounds Insecticides BAYER CROPSCIENCE AG (DE) 2007-12-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130743-A1 HETEROCYCLE-SUBSTITUTED, N-PHENYL-PHTHALAMIDE DERIVATIVES, RELATED COMPOUNDS AND THEIR USE AS INSECTICIDES DDT, SQOR, CYP2S1 SKP2 1205/4885ADORA3 3609/4885ADORA2A 4049/4885
US-20070299085-A1 N1-((Pyrazol-1-Ymethyl)-2-Methylphenyl)-Phatalamide Derivatives And Related Compounds Insecticides CHRM1, KCNH1, DDT SKP2 1596/4885ADORA3 1259/4885ADORA2A 2374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.