SCHEMBL28879083

SCHEMBL28879083

N#COc1cc(F)ccc1F

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CA3 P07451 1/20 0.38
CA6 P23280 1/20 0.38
CA5A P35218 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
CA5B Q9Y2D0 1/20 0.38
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
AR P10275 1/20 0.34
SLC22A12 Q96S37 1/20 0.34
ALDH1A1 P00352 1/20 0.33
NFE2L2 Q16236 2/20 0.31
IDO1 P14902 1/20 0.31
AGXT P21549 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22926401 0.83 AR (0.44) CES2CES1ARSLC22A12ALDH1A1
SCHEMBL6223094 0.78 CA3 (0.38) CA3CA6CA5ACA9CA14
SCHEMBL14703718 0.77 L3MBTL1 (0.38) ALDH1A1NFE2L2
SCHEMBL9487857 0.74 CA3 (0.46) CA3CA6CA5ACA9CA14
SCHEMBL22926431 0.74 AR (0.48) ARALDH1A1IDO1
SCHEMBL3066192 0.74 ALOX5AP (0.46) CA3CA6CA5ACA9CA14
SCHEMBL4402520 0.72 ALDH1A1 (0.51) ALDH1A1
SCHEMBL26420008 0.71 SLC6A4 (0.43) SLC22A12ALDH1A1
SCHEMBL197623 0.70 MEN1 (0.46) CA3CA6CA5ACA9CA14
SCHEMBL29362946 0.70 MEN1 (0.46) CA3CA6CA5ACA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105358130-B A kind of isosulfocyanate compound preparation 无锡杰西医药股份有限公司 2019-11-19 CN disclosed