SCHEMBL28880690

SCHEMBL28880690

COC(=O)c1ccc(-c2ccc(C(=O)OC)cc2C#N)c(C#N)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.50
CA2 P00918 3/20 0.50
CA12 O43570 2/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
CA14 Q9ULX7 2/20 0.50
XDH P47989 1/20 0.50
PTPRC P08575 1/20 0.47
MAPT P10636 4/20 0.46
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 2/20 0.46
HPGD P15428 2/20 0.46
HSD17B10 Q99714 2/20 0.46
GAA P10253 2/20 0.46
GLA P06280 1/20 0.46
CASP1 P29466 1/20 0.46
CASP7 P55210 1/20 0.46
ATM Q13315 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
MEN1 O00255 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28577777 0.90 EGFR (0.52) CA1CA2CA12CA7CA9
SCHEMBL404224 0.88 EGFR (0.57) CA1CA2CA12CA7CA9
SCHEMBL8148281 0.87 CA1 (0.52) CA1CA2CA12CA7CA9
SCHEMBL28577779 0.86 EGFR (0.49) XDHKDM4EEGFR
SCHEMBL4598114 0.84 KDM4E (0.57) CA1CA2CA12CA7CA9
SCHEMBL399625 0.84 CA1 (0.62) CA1CA2CA12CA7CA9
SCHEMBL2478176 0.84 CA1 (0.49) CA1CA2CA12CA7CA9
SCHEMBL30863575 0.84 CA1 (0.62) CA1CA2CA12CA7CA9
SCHEMBL105391 0.83 ALDH1A1 (0.59) CA1CA2CA12CA7CA9
SCHEMBL366584 0.83 CA1 (0.47) CA1CA2CA12CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110483333-A A kind of preparation method for the polycarboxylic acid organic ligand that dicyanogen methyl isophorone replaces UNIV TONGJI 2019-11-22 CN claimed
CN-110483333-A A kind of preparation method for the polycarboxylic acid organic ligand that dicyanogen methyl isophorone replaces UNIV TONGJI 2019-11-22 CN disclosed