Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.94 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | ITGA1 | P56199 | 2/20 | 0.63 |
| ▸ | PHGDH | O43175 | 1/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30209693 | 1.00 | POLB (0.94) | POLBPFKFB3MAPTMEN1KMT2A | |
| SCHEMBL894613 | 0.91 | POLB (0.82) | POLBPFKFB3MAPTMEN1KMT2A | |
| SCHEMBL787677 | 0.90 | PFKFB3 (1.00) | POLBPFKFB3MAPTMEN1KMT2A | |
| SCHEMBL3564982 | 0.88 | POLB (0.74) | POLBPFKFB3MAPTMEN1KMT2A | |
| SCHEMBL2241495 | 0.85 | ITGA1 (0.80) | POLBPFKFB3MAPTMEN1KMT2A | |
| SCHEMBL17331335 | 0.85 | POLB (0.78) | POLBPFKFB3MAPTMEN1KMT2A | |
| SCHEMBL11025715 | 0.85 | POLB (0.78) | POLBPFKFB3MAPTMEN1KMT2A | |
| SCHEMBL812691 | 0.84 | POLB (0.67) | POLBPFKFB3MAPTMEN1KMT2A | |
| SCHEMBL788070 | 0.84 | PFKFB3 (0.83) | POLBPFKFB3MAPTMEN1KMT2A | |
| SCHEMBL788010 | 0.84 | PFKFB3 (0.83) | POLBPFKFB3MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137141-B1 | BIPHENYL-4-YL-SULFONIC ACID ARYLAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | UNIV ABERDEEN (GB) | 2015-12-02 | — | — | EP | disclosed |
| US-20150164910-A1 | ANTIVIRAL COMPOUNDS AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-18 | — | — | US | disclosed |
| US-20150164910-A1 | ANTIVIRAL COMPOUNDS AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-18 | — | — | US | disclosed |
| US-20150164910-A1 | ANTIVIRAL COMPOUNDS AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-18 | — | — | US | disclosed |
| WO-2013188848-A2 | ANTIVIRAL COMPOUNDS AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-12-19 | — | — | WO | disclosed |
| US-8524778-B2 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents | PIMCO 2664 LIMITED (GB) | 2013-09-03 | — | — | US | disclosed |
| US-8524778-B2 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents | PIMCO 2664 LIMITED (GB) | 2013-09-03 | — | — | US | disclosed |
| US-8524778-B2 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents | PIMCO 2664 LIMITED (GB) | 2013-09-03 | — | — | US | disclosed |
| US-20100286266-A1 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2010-11-11 | — | — | US | disclosed |
| US-20100286266-A1 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2010-11-11 | — | — | US | disclosed |
| US-20100286266-A1 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2010-11-11 | — | — | US | disclosed |
| EP-2137141-A1 | BIPHENYL-4-YL-SULFONIC ACID ARYLAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | The University Court of The University of Aberdeen (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008114022-A1 | BIPHENYL-4-YL-SULFONIC ACID ARYLAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008114022-A1 | BIPHENYL-4-YL-SULFONIC ACID ARYLAMIDES AND THEIR USE AS THERAPEUTIC AGENTS | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286266-A1 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents | ARSA, SOST, AHR | POLB 3123/4885PFKFB3 1200/4885MAPT 1659/4885 |
| US-20150164910-A1 | ANTIVIRAL COMPOUNDS AND METHODS OF USE | EIF2AK2, RNASE1, HAVCR2 | POLB 256/4885PFKFB3 3188/4885MAPT 4474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.