Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.37 |
| ▸ | OTC | P00480 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4398586 | 0.98 | PRCP (0.36) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL4396599 | 0.96 | PRCP (0.35) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL28818309 | 0.95 | GSR (0.37) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL27649411 | 0.95 | PRCP (0.34) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL8587127 | 0.92 | ALOX15 (0.33) | PRCPKMT2A | |
| Arginine SCHEMBL11905364 | 0.92 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL1840912 | 0.92 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL17113848 | 0.92 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL20242303 | 0.92 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL15941091 | 0.92 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111273011-A | Application of FKBP38 protein in breast cancer diagnosis | 广东工业大学 | 2020-06-12 | — | — | CN | disclosed |
| CN-110672859-A | Biomarker for diagnosing endometrial cancer and diagnostic kit using antibody thereof | 广东工业大学 | 2020-01-10 | — | — | CN | disclosed |