Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.36 |
| ▸ | OTC | P00480 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 3/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL28880704 | 0.98 | PRCP (0.37) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL4396599 | 0.94 | PRCP (0.35) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL11905364 | 0.94 | PRCP (0.40) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL27649411 | 0.93 | PRCP (0.34) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL28818309 | 0.93 | GSR (0.37) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL6369693 | 0.93 | PRCP (0.37) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL27036832 | 0.91 | PRCP (0.39) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL11905026 | 0.91 | PRCP (0.37) | PRCPOTCDDAH1NOS2NOS3 | |
| Arginine SCHEMBL8587127 | 0.90 | ALOX15 (0.33) | PRCP | |
| Arginine SCHEMBL6535144 | 0.90 | PRCP (0.37) | PRCPOTCDDAH1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062206-A1 | Urodilatin Cancer Treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2009-03-05 | — | — | US | disclosed |