Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | LAP3 | P28838 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28884667 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2HIF1AKMT2APARP10FFAR1 | |
| SCHEMBL29019464 | 0.90 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1AKMT2AMAPTFABP7 | |
| SCHEMBL27522574 | 0.90 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1AKMT2AMAPTFABP7 | |
| SCHEMBL5264305 | 0.90 | SMN1; SMN2 (0.55) | SMN1; SMN2HIF1AKMT2AMAPTFABP7 | |
| SCHEMBL1311053 | 0.87 | FABP5 (0.44) | SMN1; SMN2HIF1AKMT2AGAAFABP7 | |
| SCHEMBL29019435 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2HIF1AKMT2APPARGFABP7 | |
| SCHEMBL28356620 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2HIF1AKMT2APPARGFABP7 | |
| SCHEMBL29019459 | 0.85 | SMN1; SMN2 (0.42) | SMN1; SMN2HIF1AKMT2APPARGFABP7 | |
| SCHEMBL31522725 | 0.85 | LTA4H (0.44) | SMN1; SMN2HIF1AKMT2AMAPTRAB9A | |
| SCHEMBL16634841 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2HIF1AKMT2APPARGFABP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117615792-A | Conjugates of checkpoint inhibitors with IL-2 and uses thereof | 明峰治疗股份公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-117615794-A | Checkpoint inhibitors conjugated to IL-2 and uses thereof | 明峰治疗股份公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-117615793-A | Antibody conjugates and their preparation | 明峰治疗股份公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-117616036-A | Modified IL-2 polypeptides for the treatment of inflammatory and autoimmune diseases | 明峰治疗股份公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-115315436-A | Modified IL-2 polypeptides and uses thereof | 明峰治疗股份公司 | 2022-11-08 | — | — | CN | disclosed |