Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | APP | P05067 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.45 |
| ▸ | ALPG | P10696 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | VDR | P11473 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL28888918 | 1.00 | MAPT (0.54) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL10071789 | 0.85 | MAPT (0.54) | MAPTAPPMEN1KMT2ALMNA | |
| Iodide SCHEMBL29249905 | 0.85 | MAPT (0.70) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL8995923 | 0.83 | MAPT (0.68) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL16253381 | 0.83 | MAPT (0.68) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL17320723 | 0.83 | MAPT (0.55) | MAPTAPPMEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL14675272 | 0.82 | MAPT (0.67) | MAPTAPPMEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL29429013 | 0.82 | MAPT (0.67) | MAPTAPPMEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL14674430 | 0.82 | MAPT (0.67) | MAPTAPPMEN1KMT2ALMNA | |
| Iodide SCHEMBL28090457 | 0.82 | MAPT (0.61) | MAPTAPPMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111056985-A | Partially cyanine derivative fluorescent probe and preparation method and application thereof | 广州大学 | 2020-04-24 | — | — | CN | disclosed |