Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | RORB | Q92753 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28959168 | 0.86 | HDAC4 (0.44) | ADRB2NOS3NOS2NR3C2TRPV3 | |
| SCHEMBL28889339 | 0.86 | ADRB2 (0.42) | ADRB2NOS3NOS2ALDH1A1NR3C2 | |
| SCHEMBL28889367 | 0.85 | ADRB2 (0.41) | ADRB2NOS3NOS2ALDH1A1NR3C2 | |
| SCHEMBL28889288 | 0.84 | MEN1 (0.39) | ADRB2EPAS1NOS3NOS2MEN1 | |
| SCHEMBL29893638 | 0.84 | MEN1 (0.39) | ADRB2EPAS1NOS3NOS2MEN1 | |
| SCHEMBL28994016 | 0.83 | ADRB2 (0.40) | ADRB2RORBTRPV3MAPTKDM4E | |
| SCHEMBL28889298 | 0.82 | ADRB2 (0.39) | ADRB2NOS3NOS2MEN1KMT2A | |
| SCHEMBL24110333 | 0.82 | TACR1 (0.45) | ADRB2NOS3NOS2ALDH1A1 | |
| SCHEMBL28889231 | 0.81 | GLA (0.39) | OPRL1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL28889307 | 0.81 | ADRB2 (0.38) | ADRB2NOS3NOS2ALDH1A1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115867541-A | Aminopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-03-28 | — | — | CN | disclosed |
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |