Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29942331 | 0.89 | ADRB2 (0.38) | KMT2AADRB2P2RY1LMNAPOLB | |
| SCHEMBL28889178 | 0.89 | HDAC4 (0.43) | KMT2AMEN1ADRB2P2RY1LMNA | |
| SCHEMBL28889187 | 0.89 | MEN1 (0.40) | KMT2AMEN1ADRB2LMNAPOLB | |
| SCHEMBL28889319 | 0.88 | ADRB2 (0.41) | KMT2AMEN1ADRB2ALDH1A1MAPT | |
| SCHEMBL28889382 | 0.86 | ADRB2 (0.39) | KMT2AMEN1ADRB2P2RY1LMNA | |
| SCHEMBL29941697 | 0.85 | MEN1 (0.49) | KMT2AMEN1ADRB2POLBALDH1A1 | |
| SCHEMBL28959159 | 0.84 | ADRB2 (0.38) | KMT2AADRB2P2RY1LMNAPOLB | |
| SCHEMBL28889349 | 0.83 | P2RY1 (0.41) | KMT2AMEN1ADRB2P2RY1LMNA | |
| SCHEMBL28889367 | 0.82 | ADRB2 (0.41) | ADRB2RIOK2ALDH1A1TRPV3KCNN4 | |
| SCHEMBL28889179 | 0.81 | KMT2A (0.41) | KMT2AMEN1ADRB2P2RY1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |