Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941978 | 0.90 | MEN1 (0.40) | ADRB2POLBLMNACNR2CNR1 | |
| SCHEMBL29941767 | 0.85 | ADRB2 (0.39) | ADRB2NPSR1POLBMAPTGAA | |
| SCHEMBL29941818 | 0.84 | HDAC4 (0.41) | ADRB2NPSR1POLBMAPTGAA | |
| SCHEMBL29941821 | 0.83 | ADRB2 (0.39) | ADRB2NPSR1POLBMAPTGAA | |
| SCHEMBL28889196 | 0.83 | TACR1 (0.43) | ADRB2NPSR1MAPTLMNAKDM4E | |
| SCHEMBL29941803 | 0.82 | HDAC4 (0.42) | ADRB2NPSR1POLBMAPTGAA | |
| SCHEMBL29941839 | 0.82 | PHGDH (0.41) | ADRB2NPSR1POLBMAPTGAA | |
| SCHEMBL29941794 | 0.80 | ADRB2 (0.38) | ADRB2NPSR1POLBMAPTGAA | |
| SCHEMBL29942364 | 0.80 | ADRB2 (0.40) | ADRB2MAPTGAAPHGDHKDM4E | |
| SCHEMBL28889385 | 0.79 | NR3C2 (0.40) | ADRB2CNR2TRPV3NR3C2KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |