Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14241102 | 0.78 | BTK (0.34) | HPGDSIRAK4CHRM4EGFRBTK | |
| SCHEMBL23555498 | 0.78 | IRAK4 (0.44) | HPGDSMAP4K4IRAK4CYP3A4EGFR | |
| SCHEMBL767164 | 0.78 | HPGDS (0.42) | HPGDSMAP4K4IRAK4CHRM4CYP3A4 | |
| SCHEMBL19005056 | 0.77 | HPGDS (0.40) | HPGDSMAP4K4IRAK4EGFRLMNA | |
| SCHEMBL18557416 | 0.75 | GPR119 (0.56) | MAP4K4IRAK4HTTBTK | |
| SCHEMBL14165818 | 0.74 | IRAK1 (0.41) | LMNABTK | |
| SCHEMBL14165369 | 0.74 | IRAK1 (0.41) | LMNABTK | |
| SCHEMBL29740638 | 0.74 | IRAK1 (0.41) | LMNABTK | |
| SCHEMBL14165368 | 0.74 | IRAK1 (0.41) | LMNABTK | |
| SCHEMBL14165782 | 0.74 | IRAK1 (0.41) | LMNABTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111253397-B | MNK inhibitors | 上海迪诺医药科技有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-111253397-A | MNK inhibitors | 上海迪诺医药科技有限公司 | 2020-06-09 | — | — | CN | disclosed |