Sugi Predict

Sugi Predict / Compounds / SCHEMBL2889115

SCHEMBL2889115

SCHEMBL2889115

Cc1ccc(CO)c(N)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 3/20 0.52
▸ TDP1 Q9NUW8 2/20 0.52
▸ CYP3A4 P08684 2/20 0.52
▸ SMN1; SMN2 Q16637 2/20 0.52
▸ TP53 P04637 1/20 0.52
▸ THRB P10828 1/20 0.52
▸ ALDH1A1 P00352 5/20 0.52
▸ HSD17B10 Q99714 2/20 0.52
▸ CA1 P00915 1/20 0.45
▸ SLC6A4 P31645 4/20 0.41
▸ SLC6A2 P23975 3/20 0.41
▸ SLC6A3 Q01959 3/20 0.41
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ TAAR1 Q96RJ0 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7872556 0.83 ALDH1A1 (0.48) ALOX15TDP1CYP3A4SMN1; SMN2TP53
SCHEMBL356244 0.82 ALOX15 (0.52) ALOX15TDP1CYP3A4SMN1; SMN2TP53
SCHEMBL5252467 0.81 TDP1 (0.56) ALOX15TDP1CYP3A4SMN1; SMN2TP53
SCHEMBL29617187 0.81 ALOX15 (0.56) ALOX15TDP1CYP3A4SMN1; SMN2TP53
SCHEMBL4001757 0.81 ALOX15 (0.56) ALOX15TDP1CYP3A4SMN1; SMN2TP53
SCHEMBL30316721 0.81 ALOX15 (0.56) ALOX15TDP1CYP3A4SMN1; SMN2TP53
SCHEMBL5032198 0.81 ALOX15 (0.56) ALOX15TDP1CYP3A4SMN1; SMN2TP53
SCHEMBL2540787 0.79 ALDH1A1 (0.45) ALOX15TDP1CYP3A4SMN1; SMN2TP53
SCHEMBL31472985 0.79 ALOX15 (0.54) ALOX15TDP1CYP3A4SMN1; SMN2TP53
SCHEMBL1261761 0.79 ALOX15 (0.54) ALOX15TDP1CYP3A4SMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116375641-B C3-phenoxy substituted quinoline compound and synthetic method and application thereof 杭州师范大学 2025-01-03 — — CN disclosed
EP-4393937-A1 STEROID COMPOUND AND CONJUGATE THEREOF Duality Biologics (Suzhou) Co., Ltd. (CN) 2024-07-03 — — EP disclosed
CN-115850200-B Polymerizable 3, 1-benzoxazine substituted phenol monomer, preparation method, cured product and application 西安交通大学 2024-05-14 — — CN disclosed
CN-114031507-B Synthesis method of o-aminobenzyl alcohol compound 辽宁科信生物科技有限公司 2024-03-22 — — CN disclosed
CN-116375641-A C3-phenoxy substituted quinoline compound and synthetic method and application thereof 杭州师范大学 2023-07-04 — — CN disclosed
CN-115073473-B Seven-membered ring indoloazepine CYP1B1 enzyme inhibitor, and preparation method and application thereof 海南大学 2023-06-23 — — CN disclosed
CN-115057807-B 3- (2-isocyanobenzyl) indole derivative quorum sensing inhibitor and preparation method and application thereof 海南大学 2023-06-23 — — CN disclosed
US-11655269-B2 Prodrug-type anticancer agent using cancer-specific enzymatic activity THE UNIVERSITY OF TOKYO (JP) 2023-05-23 — — US disclosed
US-11655269-B2 Prodrug-type anticancer agent using cancer-specific enzymatic activity THE UNIVERSITY OF TOKYO (JP) 2023-05-23 — — US disclosed
CN-114031507-A Synthetic method of anthranilic alcohol compound 辽宁科信生物科技有限公司 2022-02-11 — — CN disclosed
EP-2287162-A1 Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders Otsuka Pharmaceutical Co., Ltd. (JP) 2011-02-23 — — EP disclosed
EP-2287161-A1 Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders Otsuka Pharmaceutical Co., Limited (JP) 2011-02-23 — — EP disclosed
EP-2284169-A1 Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of CNS disorders Otsuka Pharmaceutical Co., Limited (JP) 2011-02-16 — — EP disclosed
US-20100035942-A1 1-orthofluorophenyl substituted 1,2,5-thiazolidinedione derivatives as ptp-as inhibitors NOVARTIS AG (CH) 2010-02-11 — — US disclosed
EP-1963293-A1 1-ORTHOFLUOROPHENYL SUBSTITUTED 1, 2 , 5-THIAZOLIDINEDIONE DERIVATIVES AS PTP-AS INHIBITORS Novartis AG (CH) 2008-09-03 — — EP disclosed
WO-2007117180-A1 AZAHETEROCYCLES, COMBINATORY LIBRARY, FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION AND METHODS FOR THE PRODUCTION THEREOF 'CHEMICAL DIVERSITY RESEARCH INSTITUTE' LTD. (RU) 2007-10-18 — — WO disclosed
WO-2007067612-A1 1-ORTHOFLUOROPHENYL SUBSTITUTED 1, 2, 5-THIAZOLIDINEDIONE DERIVATIVES AS PTP-AS INHIBITORS NOVARTIS AG (CH) 2007-06-14 — — WO disclosed
WO-2007026959-A2 DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-03-08 — — WO disclosed
EP-0773944-A1 BENZYL-IMIDAZOPYRIDINES Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1997-05-21 — — EP disclosed
WO-1996003403-A1 BENZYL-IMIDAZOPYRIDINES BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1996-02-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11655269-B2 Prodrug-type anticancer agent using cancer-specific enzymatic activity GUSB, NTPCR, FOLH1 ALOX15 3013/4885TDP1 358/4885CYP3A4 489/4885
US-20100035942-A1 1-orthofluorophenyl substituted 1,2,5-thiazolidinedione derivatives as ptp-as inhibitors PTPRS, PTPRF, PTPRO ALOX15 427/4885TDP1 926/4885CYP3A4 3567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.