Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3599142 | 0.84 | KCNE1 (0.40) | L3MBTL1ALDH1A1MAPK1PTK2B | |
| SCHEMBL3599146 | 0.84 | KCNE1 (0.40) | L3MBTL1ALDH1A1MAPK1PTK2B | |
| SCHEMBL2011332 | 0.81 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2HTTTDP1GAA | |
| SCHEMBL2011333 | 0.81 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2HTTTDP1GAA | |
| SCHEMBL2012198 | 0.81 | NPC1 (0.39) | L3MBTL1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL12580760 | 0.79 | ABCB1 (0.42) | — | |
| SCHEMBL4941253 | 0.74 | ALDH1A1 (0.37) | L3MBTL1ALDH1A1MAPK1PTK2BSMN1; SMN2 | |
| SCHEMBL2875594 | 0.71 | KCNA5 (0.42) | ALDH1A1SMN1; SMN2HTTGAAALOX5 | |
| SCHEMBL13199529 | 0.70 | ABCB1 (0.43) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL12580677 | 0.66 | ABCB1 (0.41) | ALDH1A1SMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652008-B2 | 2,2,7,9-tetramethyl-4-[(2-phenylethyl)amino]-3,4-dihydro-2H-pyrano[2,3-g]quinolin-3-ol; 3-hydroxy-2,2,9-trimethyl-4-[(2-phenylethyl)amino]-3,4-dihydro-2H-pyrano[2,3-g]quinolin-7-carbonitrile; have the prolongation effect on refractory period | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-01-26 | — | — | US | disclosed |