Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TPO | P07202 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TK2 | O00142 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896358 | 0.81 | MPO (0.61) | MPOOPRM1L3MBTL1ADORA2AKDM1A | |
| SCHEMBL29211241 | 0.67 | MPO (0.47) | MPOOPRM1GAAMEN1KMT2A | |
| SCHEMBL29211290 | 0.66 | MPO (0.48) | MPOOPRM1GAAMEN1KMT2A | |
| SCHEMBL29211286 | 0.65 | MPO (0.47) | MPOGAAMEN1KMT2ATPO | |
| SCHEMBL28896211 | 0.65 | MPO (0.58) | MPOOPRM1GAAMEN1KMT2A | |
| SCHEMBL30028868 | 0.65 | MPO (0.31) | MPOTPO | |
| SCHEMBL28896226 | 0.64 | MPO (0.31) | MPOTPO | |
| SCHEMBL8223760 | 0.63 | MPO (0.67) | MPOOPRM1TPOCYP3A4 | |
| SCHEMBL1536715 | 0.61 | ALDH1A1 (0.42) | MPOOPRM1ADORA2AGAAMEN1 | |
| SCHEMBL1461123 | 0.59 | PDE4A (0.57) | MPOOPRM1ADORA2ATPOCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |