Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 11/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896320 | 0.84 | JAK1 (0.37) | ATMMAPTNPSR1ALOX15JAK1 | |
| SCHEMBL28896607 | 0.77 | ATM (0.38) | ATMMAPTNPSR1ALOX15JAK1 | |
| SCHEMBL1536637 | 0.76 | KDM4E (0.49) | ATMMAPTNPSR1ALOX15JAK1 | |
| SCHEMBL28896299 | 0.73 | PTGER4 (0.34) | MAPTNPSR1MEN1KMT2A | |
| SCHEMBL28896264 | 0.73 | PTGER4 (0.34) | MAPTNPSR1MEN1KMT2A | |
| SCHEMBL1536735 | 0.73 | ACKR3 (0.48) | ATMMAPTNPSR1ALOX15JAK1 | |
| SCHEMBL28896591 | 0.72 | ALDH1A1 (0.34) | MAPTNPSR1KMT2A | |
| SCHEMBL29211239 | 0.72 | NR1H2 (0.46) | ATMMAPTNPSR1ALOX15JAK1 | |
| SCHEMBL27223558 | 0.71 | HDAC1 (0.41) | ATMMAPTNPSR1ALOX15JAK1 | |
| SCHEMBL28896764 | 0.71 | PTGER4 (0.34) | MAPTNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |