Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.80 |
| ▸ | GLA | P06280 | 1/20 | 0.80 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | MDM4 | O15151 | 2/20 | 0.59 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023209 | 0.91 | MAPT (0.83) | TDP1MAPTALDH1A1L3MBTL1GLA | |
| SCHEMBL4233761 | 0.87 | TDP1 (0.77) | TDP1MAPTALDH1A1L3MBTL1GLA | |
| SCHEMBL11163161 | 0.85 | MAPT (0.73) | TDP1MAPTALDH1A1L3MBTL1GLA | |
| SCHEMBL4654049 | 0.84 | TDP1 (0.72) | TDP1MAPTALDH1A1L3MBTL1GLA | |
| SCHEMBL34933 | 0.84 | TDP1 (0.72) | TDP1MAPTALDH1A1L3MBTL1GLA | |
| SCHEMBL26264767 | 0.84 | TDP1 (0.71) | TDP1MAPTALDH1A1L3MBTL1GLA | |
| SCHEMBL28189189 | 0.82 | KMT2A (0.76) | TDP1MAPTALDH1A1L3MBTL1HPGD | |
| SCHEMBL7722993 | 0.81 | MAPT (0.68) | TDP1MAPTALDH1A1L3MBTL1GLA | |
| SCHEMBL11535756 | 0.80 | MAPT (0.66) | TDP1MAPTALDH1A1L3MBTL1GLA | |
| SCHEMBL1110180 | 0.79 | MDM4 (0.73) | TDP1MAPTHPGDPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109369504-B | Preparation method of sulfur-containing 3-methylene isoindoline-1-ketone derivative | 温州大学 | 2020-05-12 | — | — | CN | disclosed |