Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Prolonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prolonium SCHEMBL1649967 | 0.96 | MAPT (0.52) | MAPTSLC22A16SMN1; SMN2GALR3BLM | |
| SCHEMBL13380702 | 0.93 | MAPT (0.52) | MAPTSLC22A16SMN1; SMN2GALR3BLM | |
| Prolonium SCHEMBL1650849 | 0.92 | MAPT (0.50) | MAPTSLC22A16SMN1; SMN2GALR3BLM | |
| Prolonium SCHEMBL5705670 | 0.92 | MAPT (0.50) | MAPTSLC22A16SMN1; SMN2GALR3BLM | |
| Prolonium SCHEMBL11723705 | 0.92 | MAPT (0.50) | MAPTSLC22A16SMN1; SMN2GALR3BLM | |
| Hydrochloric Acid SCHEMBL9819532 | 0.83 | MAPT (0.50) | MAPTSLC22A16SMN1; SMN2GALR3BLM | |
| Hydrochloric Acid SCHEMBL35525 | 0.83 | MAPT (0.50) | MAPTSLC22A16SMN1; SMN2GALR3BLM | |
| SCHEMBL16405718 | 0.83 | MAPT (0.44) | MAPTSLC22A16SMN1; SMN2GALR3BLM | |
| Hydrochloric Acid SCHEMBL28705517 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL872025 | 0.81 | MAPT (0.48) | MAPTSLC22A16SMN1; SMN2GALR3BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688905-B2 | Methods for enhancing propped fracture conductivity | HALLIBURTON ENERGY SERVICES, INC. (US) | 2017-06-27 | — | — | US | claimed |
| US-20160053160-A1 | METHODS FOR ENHANCING PROPPED FRACTURE CONDUCTIVITY | HALLIBURTON ENERGY SERVICES, INC. | 2016-02-25 | — | — | US | claimed |
| WO-2015069293-A1 | METHODS FOR ENHANCING PROPPED FRACTURE CONDUCTIVITY | HALLIBURTON ENERGY SERVICES, INC. (US) | 2015-05-14 | — | — | WO | claimed |
| US-20040235677-A1 | Methods and compositions for stabilizing swelling clays or migrating fines in formations | HALLIBURTON ENERGY SERVICES, INC. | 2004-11-25 | — | — | US | claimed |
| US-5145558-A | Optical brightener | THE DOW CHEMICAL COMPANY (US) | 1992-09-08 | — | — | US | claimed |
| EP-0429241-A1 | Process for alkaline peroxide bleaching of wood pulp using a quaternary amine as additive | THE DOW CHEMICAL COMPANY (US) | 1991-05-29 | — | — | EP | claimed |
| US-5013404-A | Paper with improved brightness | THE DOW CHEMICAL COMPANY (US) | 1991-05-07 | — | — | US | claimed |
| JP-59129218-A | — | — | None | — | — | JP | disclosed |
| JP-59129216-A | — | — | None | — | — | JP | disclosed |
| JP-59129217-A | — | — | None | — | — | JP | disclosed |
| US-9688905-B2 | Methods for enhancing propped fracture conductivity | HALLIBURTON ENERGY SERVICES, INC. (US) | 2017-06-27 | — | — | US | disclosed |
| EP-2010573-B1 | CATIONIC POLYSACCHARIDE, ITS PREPARATION AND USE | CHEMIGATE OY (FI) | 2017-03-29 | — | — | EP | disclosed |
| EP-2192228-B1 | USE OF CATIONIC STARCH | CHEMIGATE OY (FI) | 2017-03-29 | — | — | EP | disclosed |
| EP-0371823-A1 | Crystalline 3-methacryloyloxy-2-hydroxypropyl-trimethylammonium chloride monomer | POLYPURE INC. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0371821-A1 | A process for the production of substituted acryloyloxyhydroxypropyltrialkylammonium chloride | RHONE-POULENC SPECIALTY CHEMICALS CO. (US) | 1990-06-06 | — | — | EP | disclosed |
| WO-1988000582-A1 | METHOD OF PURIFYING 3-CHLORO-2-HYDROXYPROPYL TRIALKYLAMMONIUM CHLORIDE | THE DOW CHEMICAL COMPANY (US) | 1988-01-28 | — | — | WO | disclosed |
| US-4602110-A | FORMING AQUEOUS SLURRY, PRECIPITATING WITH ALCOHOL | THE DOW CHEMICAL COMPANY (US) | 1986-07-22 | — | — | US | disclosed |
| JP-S59129218-A | RENDERING POLYESTER (METH)ACRYLATE RESIN THIXOTROPIC | NIPPON SHOKUBAI KAGAKU KOGYO CO LTD | 1984-07-25 | — | — | JP | disclosed |
| JP-S59129216-A | RENDERING POLY(METH)ACRYLATE RESIN THIXOTROPIC | NIPPON SHOKUBAI KAGAKU KOGYO CO LTD | 1984-07-25 | — | — | JP | disclosed |
| JP-S59129217-A | RENDERING UNSATURATED POLYESTER RESIN THIXOTROPIC | NIPPON SHOKUBAI KAGAKU KOGYO CO LTD | 1984-07-25 | — | — | JP | disclosed |