Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Prolonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prolonium SCHEMBL1649967 | 0.96 | MAPT (0.52) | MAPTSLC22A16TSHRCHRM2CHRM4 | |
| Prolonium SCHEMBL11723705 | 0.92 | MAPT (0.50) | MAPTSLC22A16TSHRCHRM2CHRM4 | |
| Prolonium SCHEMBL5705670 | 0.92 | MAPT (0.50) | MAPTSLC22A16TSHRCHRM2CHRM4 | |
| Prolonium SCHEMBL2889745 | 0.92 | MAPT (0.57) | MAPTSLC22A16TSHRCHRM2CHRM4 | |
| SCHEMBL13380702 | 0.86 | MAPT (0.52) | MAPTSLC22A16TSHRCHRM2CHRM4 | |
| Iodide SCHEMBL4083174 | 0.83 | LMNA (0.47) | MAPTSLC22A16TSHRCHRM2CHRM4 | |
| Iodide SCHEMBL9421128 | 0.81 | — | — | |
| Iodide SCHEMBL23501735 | 0.81 | MAPT (0.42) | MAPTSLC22A16TSHRCHRM2CHRM4 | |
| Iodide SCHEMBL28809264 | 0.81 | MAPT (0.42) | MAPTSLC22A16TSHRCHRM2CHRM4 | |
| SCHEMBL15761654 | 0.81 | MAPT (0.42) | MAPTSLC22A16TSHRCHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103191491-A | Packing material, and purpose and manufacturing method thereof | ZHA HONGMEI | 2013-07-10 | — | — | CN | claimed |
| CN-1751703-A | Injection for treating ophthalmopathy | DUAN YADONG (CN) | 2006-03-29 | — | — | CN | claimed |
| CN-120736810-B | AF film layer with high hardness and high wear resistance, glass product, preparation method and application | 湖南天氟新材料有限公司 | 2025-11-07 | — | — | CN | disclosed |
| CN-120736810-A | AF film layer with high hardness and high wear resistance, glass product, preparation method and application | 湖南天氟新材料有限公司 | 2025-10-03 | — | — | CN | disclosed |
| CN-111886592-B | Method and system for performing inlining on sliced data sets | 谷歌有限责任公司 | 2025-04-22 | — | — | CN | disclosed |
| CN-118939685-A | Query statement self-connection elimination method, device, equipment and storage medium | 中电科金仓(北京)科技股份有限公司 | 2024-11-12 | — | — | CN | disclosed |
| EP-4388874-A1 | PARTICULATE WEED CONTROL | Bind-X GmbH (DE) | 2024-06-26 | — | — | EP | disclosed |
| CN-117790035-A | Slurry curing system containing radioactive elements | 中国原子能科学研究院 | 2024-03-29 | — | — | CN | disclosed |
| US-20240090506-A1 | SURFACE MODIFICATION TO REGULATE PLANT GROWTH | BIND-X INTERNATIONAL GMBH (DE) | 2024-03-21 | — | — | US | disclosed |
| CN-117461511-A | Method for promoting growth and development of fir seedlings through moss coverage | 中国科学院成都生物研究所 | 2024-01-30 | — | — | CN | disclosed |
| EP-4250922-A1 | SURFACE MODIFICATION TO REGULATE PLANT GROWTH | Bind-X GmbH (DE) | 2023-10-04 | — | — | EP | disclosed |
| US-20020102215-A1 | Diagnostic/therapeutic agents | NYCOMED IMAGING AS | 2002-08-01 | — | — | US | disclosed |
| US-20020102217-A1 | Diagnostic/therapeutic agents | NYCOMED IMAGING AS | 2002-08-01 | — | — | US | disclosed |
| US-6331289-B1 | ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED | NYCOMED IMAGING AS (NO) | 2001-12-18 | — | — | US | disclosed |
| CN-1323592-A | Dressed composite medicine for treating vitreous body diseases | ZHU WEIGUO (CN) | 2001-11-28 | — | — | CN | disclosed |
| US-6264917-B1 | MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT | NYCOMED IMAGING AS (NO) | 2001-07-24 | — | — | US | disclosed |
| US-6261537-B1 | TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES | NYCOMED IMAGING AS (NO) | 2001-07-17 | — | — | US | disclosed |
| CN-1225271-A | Pearl eyesight improvement drops contg vitamin C | CHEN ZHONGRONG (CN) | 1999-08-11 | — | — | CN | disclosed |
| CN-1225271-A | Pearl eyesight improvement drops contg vitamin C | CHEN ZHONGRONG (CN) | 1999-08-11 | — | — | CN | disclosed |
| CN-1135357-A | Medicinal composition for treatment of unmatured catarct | ZHU JIN (CN) | 1996-11-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020102215-A1 | Diagnostic/therapeutic agents | BID, FUS, FABP1 | CHRM1 4583/4885CHRM3 4193/4885MAPT 2239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.