Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.53 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28442021 | 0.87 | POLB (0.45) | STAT6LMNAMAPK9MAPK10 | |
| SCHEMBL28441103 | 0.86 | MAPK9 (0.47) | JAK3AKR1C3STAT6LMNAJAK2 | |
| SCHEMBL28897515 | 0.84 | JAK3 (0.62) | LRRK2JAK3FLT3KITPTK2 | |
| SCHEMBL28443297 | 0.84 | JAK2 (0.60) | LRRK2JAK3FLT3JAK2 | |
| SCHEMBL28437345 | 0.79 | JAK2 (0.54) | FLT3JAK2 | |
| SCHEMBL28447917 | 0.74 | MAPK9 (0.44) | JAK3FLT3STAT6JAK2MAPK9 | |
| SCHEMBL28434558 | 0.74 | PIK3CD (0.53) | AKR1C3 | |
| SCHEMBL28451619 | 0.73 | MAPK9 (0.48) | LRRK2JAK3LMNAJAK2MAPK9 | |
| SCHEMBL17544904 | 0.72 | PTK2 (0.46) | AKR1C3PTK2LMNAULK1MAPK9 | |
| SCHEMBL29706102 | 0.72 | FLT3 (0.67) | LRRK2JAK3FLT3KITPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | claimed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |