Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 4/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.44 |
| ▸ | STAT6 | P42226 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437336 | 0.89 | JAK2 (0.47) | MAPK9MAPK10STAT6JAK2JAK3 | |
| SCHEMBL28441103 | 0.85 | MAPK9 (0.47) | MAPK9MAPK10STAT6JAK2JAK3 | |
| SCHEMBL28439360 | 0.84 | JAK2 (0.63) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL28441100 | 0.82 | JAK2 (0.61) | MAPK9MAPK10STAT6JAK2JAK3 | |
| SCHEMBL28447910 | 0.80 | JAK3 (0.65) | MAPK9MAPK10JAK2JAK3JAK1 | |
| SCHEMBL28442021 | 0.75 | POLB (0.45) | MAPK9MAPK10STAT6TYK2NPC1 | |
| SCHEMBL28437333 | 0.75 | JAK2 (0.50) | MAPK9MAPK10STAT6JAK2JAK3 | |
| SCHEMBL28897517 | 0.74 | LRRK2 (0.53) | MAPK9MAPK10STAT6JAK2JAK3 | |
| SCHEMBL28451619 | 0.73 | MAPK9 (0.48) | MAPK9MAPK10JAK2JAK3JAK1 | |
| SCHEMBL28442012 | 0.71 | JAK2 (0.57) | MAPK9MAPK10STAT6JAK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |