Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.78 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646283 | 0.87 | KDM4E (1.00) | ALPLKDM4EALDH1A1HSD17B10THRB | |
| SCHEMBL13539296 | 0.86 | ALPL (0.78) | ALPLKDM4EALDH1A1HSD17B10THRB | |
| SCHEMBL13542004 | 0.83 | ALDH1A1 (0.72) | ALPLKDM4EALDH1A1HSD17B10THRB | |
| SCHEMBL13539297 | 0.81 | ALPL (1.00) | ALPLKDM4EALDH1A1HSD17B10THRB | |
| SCHEMBL13539303 | 0.80 | ALDH1A1 (0.67) | ALPLKDM4EALDH1A1HSD17B10RAB9A | |
| SCHEMBL30759606 | 0.78 | GSR (0.58) | ALPLKDM4EALDH1A1HSD17B10CCNA2 | |
| SCHEMBL30290797 | 0.75 | KDM4E (0.51) | ALPLKDM4EALDH1A1HSD17B10THRB | |
| SCHEMBL10176736 | 0.75 | ALPL (0.61) | ALPLKDM4EALDH1A1HSD17B10THRB | |
| SCHEMBL4149139 | 0.72 | ALPL (0.67) | ALPLKDM4EALDH1A1HSD17B10THRB | |
| SCHEMBL2171482 | 0.68 | KDM4E (0.59) | ALPLKDM4EALDH1A1HSD17B10THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531721-B | Fused tricyclic pyrazole derivatives for modulating farnesoid X receptors | 诺华股份有限公司 | 2020-07-17 | — | — | CN | claimed |
| CN-107531721-B | Fused tricyclic pyrazole derivatives for modulating farnesoid X receptors | 诺华股份有限公司 | 2020-07-17 | — | — | CN | disclosed |