Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CASP9 | P55211 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30095468 | 1.00 | MAPT (0.49) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL18096563 | 0.89 | MAPT (0.53) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL28362553 | 0.82 | MAPT (0.49) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL11126322 | 0.79 | MAPT (0.50) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL10746517 | 0.79 | CDK2 (0.53) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL29027035 | 0.77 | MAPT (0.53) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL20507307 | 0.77 | MAPT (0.56) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL9400557 | 0.76 | MAPT (0.51) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL30095501 | 0.75 | BRPF1 (0.40) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL28899206 | 0.75 | BRPF1 (0.40) | MAPTMEN1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456308-B | Heterocyclic compounds as ASK inhibitors and their use | 南京圣和药业股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-109456308-A | Heterocyclic compound and its application as ASK inhibitor | 南京圣和药业股份有限公司 | 2019-03-12 | — | — | CN | disclosed |