Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28899170 | 0.89 | MAPT (0.49) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL30095468 | 0.89 | MAPT (0.49) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL20507307 | 0.81 | MAPT (0.56) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL29027035 | 0.81 | MAPT (0.53) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL9400557 | 0.79 | MAPT (0.51) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL30856658 | 0.78 | MAPT (0.50) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL379545 | 0.78 | ALDH1A1 (0.59) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL6488744 | 0.77 | MAPT (0.49) | MAPTLMNAPOLBATMCDK2 | |
| SCHEMBL5327849 | 0.77 | CDK2 (0.56) | MAPTL3MBTL1MEN1KMT2APOLB | |
| SCHEMBL29540778 | 0.77 | MAPT (0.53) | MAPTL3MBTL1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025088534-A1 | BICYCLIC HETEROCYCLE COMPOUNDS AS TEAD INHIBITOR | DONG-A ST CO., LTD. (KR) | 2025-05-01 | — | — | WO | disclosed |
| US-10385036-B2 | Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof | PFIZER INC. (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180273504-A1 | Sulfonamide-Substituted Indole Modulators of RORC2 and Methods of Use Thereof | PFIZER INC. (US) | 2018-09-27 | — | — | US | disclosed |
| WO-2016120850-A9 | SULFONAMIDE-SUBSITUTED INDOLE MODULATORS OF RORC2 AND METHODS OF USE THEREOF | PFIZER INC. (US) | 2017-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180273504-A1 | Sulfonamide-Substituted Indole Modulators of RORC2 and Methods of Use Thereof | RORC, RORB, RORA | MAPT 3810/4885L3MBTL1 4725/4885MEN1 4058/4885 |
| US-10385036-B2 | Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof | RORC, RORB, RORA | MAPT 3939/4885L3MBTL1 4826/4885MEN1 4071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.