Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.44 |
| ▸ | F2R | P25116 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540778 | 0.88 | MAPT (0.53) | MAPTMEN1KMT2ALMNACDK2 | |
| SCHEMBL3354579 | 0.85 | MAPT (0.47) | MAPTMEN1KMT2ALMNACDK2 | |
| SCHEMBL10577625 | 0.84 | CDK2 (0.46) | MAPTMEN1KMT2ALMNACDK2 | |
| SCHEMBL3351876 | 0.84 | CDK2 (0.48) | MAPTMEN1KMT2ALMNACDK2 | |
| SCHEMBL3355292 | 0.83 | HTR6 (0.59) | MAPTMEN1KMT2ALMNACDK2 | |
| SCHEMBL3352978 | 0.82 | CACNB4 (0.56) | MAPTMEN1KMT2ALMNACDK2 | |
| SCHEMBL11126322 | 0.81 | MAPT (0.50) | MAPTMEN1KMT2ALMNACDK2 | |
| SCHEMBL23525638 | 0.81 | CDK2 (0.53) | MAPTMEN1KMT2ALMNACDK2 | |
| SCHEMBL3355596 | 0.81 | ALDH1A1 (0.55) | MAPTMEN1KMT2ALMNACDK2 | |
| SCHEMBL3356257 | 0.81 | CACNB4 (0.58) | MAPTMEN1KMT2ALMNACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328922-A | Anxiolytic and antidepressant activity | BEECHAM GROUP P.L.C. (GB) | 1994-07-12 | — | — | US | disclosed |
| WO-1993018026-A1 | INDOLE UREAS AS 5-HT1C RECEPTOR ANTOGONISTS | BEECHAM GROUP PLC (GB) | 1993-09-16 | — | — | WO | disclosed |
| CN-1076197-A | The preparation method of indole urea derivative | BEECHAM GROUP PLC (GB) | 1993-09-15 | — | — | CN | disclosed |
| EP-0550507-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005170-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | disclosed |