Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3SLC6A2
The experimentally established mechanism targets of Racephedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.79 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.79 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.96 |
| ▸ | LMNA | P02545 | 4/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.96 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.96 |
| ▸ | GMNN | O75496 | 1/20 | 0.96 |
| ▸ | POLB | P06746 | 1/20 | 0.96 |
| ▸ | MAPT | P10636 | 1/20 | 0.96 |
| ▸ | HPGD | P15428 | 1/20 | 0.96 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.96 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.79 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.79 |
| ▸ | RGS12 | O14924 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racephedrine SCHEMBL41263 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Racephedrine SCHEMBL10995708 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Pseudoephedrine SCHEMBL41309 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Pseudoephedrine SCHEMBL41308 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Racephedrine SCHEMBL41264 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Ephedrine SCHEMBL547932 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Ephedrine SCHEMBL41262 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Racephedrine SCHEMBL6229123 | 0.96 | ALDH1A1 (0.96) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Pseudoephedrine SCHEMBL6229122 | 0.96 | ALDH1A1 (0.96) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Racephedrine SCHEMBL23161468 | 0.91 | CYP2D6 (0.96) | ALDH1A1LMNAKDM4EKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531690-B | 4,5,6, 7-tetrahydro-1H-pyrazolo [4,3-c ] pyridin-3-amine compounds as CBP and/or EP300 inhibitors | 基因泰克公司 | 2020-11-06 | — | — | CN | disclosed |