Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Ephedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.81 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.81 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.81 |
| ▸ | RGS12 | O14924 | 1/20 | 0.81 |
| ▸ | GLA | P06280 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pseudoephedrine SCHEMBL41308 | 1.00 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Racephedrine SCHEMBL10995708 | 1.00 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Ephedrine SCHEMBL41262 | 1.00 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Racephedrine SCHEMBL41264 | 1.00 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Racephedrine SCHEMBL41263 | 1.00 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Pseudoephedrine SCHEMBL41309 | 1.00 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Pseudoephedrine SCHEMBL6229122 | 0.98 | ALDH1A1 (0.96) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Racephedrine SCHEMBL6229123 | 0.98 | ALDH1A1 (0.96) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Racephedrine SCHEMBL28900784 | 0.98 | ALDH1A1 (0.96) | ALDH1A1LMNAKDM4EKMT2ANPSR1 | |
| Ephedrine SCHEMBL4785 | 0.90 | CYP2D6 (1.00) | ALDH1A1LMNAKDM4EKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4057813-A1 | COMPOSITIONS AND METHODS FOR TREATING HUANGLONGBING DISEASE IN CITRUS | New Life Crop Sciences LLC (US) | 2022-09-21 | — | — | EP | claimed |
| US-20180344743-A1 | METHODS OF TREATMENT OF ANORECTAL AND GENITAL DISORDERS | PERITECH PHARMA LTD (IL) | 2018-12-06 | — | — | US | claimed |
| US-10085994-B2 | Topical compositions and methods of treatment of topical disorders | PERITECH PHARMA LTD. (IL) | 2018-10-02 | — | — | US | claimed |
| EP-2968133-A2 | TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF TOPICAL DISORDERS | Peritech Pharma Ltd. (IL) | 2016-01-20 | — | — | EP | claimed |
| US-9072747-B2 | Topical compositions and methods of treatment of anorectal disorders | PERITECH PHARMA LTD. (IL) | 2015-07-07 | — | — | US | claimed |
| WO-2014140925-A2 | TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF TOPICAL DISORDERS | PERITECH PHARMA LTD. (IL) | 2014-09-18 | — | — | WO | claimed |
| US-20140255521-A1 | TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF TOPICAL DISORDERS | PERITECH PHARMA LTD. (IL) | 2014-09-11 | — | — | US | claimed |
| US-20140256688-A1 | TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF ANORECTAL DISORDERS | PERITECH PHARMA LTD. (IL) | 2014-09-11 | — | — | US | claimed |
| US-20140255522-A1 | TOPICAL COMPOSITIONS AND METHODS OF TREATMENT OF ANORECTAL AND GENITAL DISORDERS | PERITECH PHARMA LTD. (IL) | 2014-09-11 | — | — | US | claimed |
| US-8679535-B2 | Sustained release matrix systems for highly soluble drugs | ENDO PHARMACEUTICALS INC. (US) | 2014-03-25 | — | — | US | claimed |
| US-20100055185-A1 | COMPOSITION AND METHOD FOR TREATING HEMORRHOIDS AND/OR ANORECTAL DISORDERS | WYETH (US) | 2010-03-04 | — | — | US | claimed |
| US-20070003627-A1 | HEMORRHOIDAL COMPOSITIONS AND METHOD OF USE | WYETH (US) | 2007-01-04 | — | — | US | claimed |
| WO-2006014259-A1 | COMPOSITION AND METHOD FOR TREATING HEMORRHOIDS AND/OR ANORECTAL DISORDERS | WYETH (US) | 2006-02-09 | — | — | WO | claimed |
| US-20060004094-A1 | Composition and method for treating hemorrhoids and/or anorectal disorders | WYETH | 2006-01-05 | — | — | US | claimed |
| US-20040037888-A1 | Hemorrhoidal compositions and method of use | WYETH | 2004-02-26 | — | — | US | claimed |
| US-20030035850-A1 | HEMORRHOIDAL COMPOSITIONS AND METHOD OF USE | WYETH | 2003-02-20 | — | — | US | claimed |
| WO-1998034628-A1 | COMPOSITION FOR THE TREATMENT OF HAEMORRHOIDS AND OTHER ANORECTAL INFLAMMATIONS | AU PHARMACEUTICALS, INC. (US) | 1998-08-13 | — | — | WO | claimed |
| US-5720962-A | Analgesic lotion for hemorrhoids and method of making such lotion | AU PHARMACEUTICALS, INC. (US) | 1998-02-24 | — | — | US | claimed |
| EP-0241615-B1 | A PHARMACEUTICAL COMPOSITION OF PHENINDAMINE HAVING ENHANCED RELEASE CHARACTERISTICS | WARNER-LAMBERT COMPANY (US) | 1991-09-18 | — | — | EP | claimed |
| EP-0241615-A1 | A pharmaceutical composition of phenindamine having enhanced release characteristics | WARNER-LAMBERT COMPANY (US) | 1987-10-21 | — | — | EP | claimed |